Association Between Serum Vitamin D and Uric Acid in the Eastern Chinese Population: a Population-based Cross-sectional Study

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2020 Jun 5

PMID 32493273

Citations 7

Authors

Yingchao Chen

Jing Cheng

Yi Chen

Ningjian Wang

Fangzhen Xia

Chi Chen

Bing Han

Yingli Lu

Affiliations

Soon will be listed here.

Abstract

Background: Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.

Methods: We did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9220 subjects were analyzed. Serum 25(OH) D, SUA, fasting plasma glucose (FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status.

Results: We enrolled 9220 Chinese adults, including 3681 males (age 55.57 ± 13.23 years) and 5539 females (age 54.31 ± 12.83 years). The levels of SUA were 352.07 ± 79.25 nmol/L and 269.29 ± 64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH) D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001).

Conclusions: SUA was positively associated with 25(OH) D in the eastern Chinese population. Higher levels of serum 25(OH) D may be a potential predictor of HUA.

Citing Articles

Association between 25 hydroxyvitamin D and serum uric acid level in the Chinese general population: a cross-sectional study.

Li S, Wang Y, Ni F, Sun T BMC Endocr Disord. 2024; 24(1):187.

PMID: 39261907 PMC: 11391835. DOI: 10.1186/s12902-024-01723-0.

25-Hydroxyvitamin D Is Associated with Islet Homeostasis in Type-2 Diabetic Patients with Abdominal Obesity.

Li Q, Zhang W, Han B, Wang Y, Wan H, Zhang M Curr Med Sci. 2023; 43(5):919-926.

PMID: 37697161 DOI: 10.1007/s11596-023-2780-z.

Association between serum uric acid levels and peripheral artery disease in Chinese adults with hypertension.

Han F, Yu C, Hu F, Zhou W, Wang T, Zhu L Front Endocrinol (Lausanne). 2023; 14:1197628.

PMID: 37674616 PMC: 10478083. DOI: 10.3389/fendo.2023.1197628.

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances.

Trimarco V, Manzi M, Mancusi C, Strisciuglio T, Fucile I, Fiordelisi A Front Cardiovasc Med. 2022; 9:859793.

PMID: 35369303 PMC: 8968037. DOI: 10.3389/fcvm.2022.859793.

Prospective Study of Serum Uric Acid Levels and First Stroke Events in Chinese Adults With Hypertension.

Hu F, Hu L, Yu R, Han F, Zhou W, Wang T Front Physiol. 2022; 12:807420.

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