Molecular Cloning and In-depth Bioinformatics Analysis of Type II Ribosome-inactivating Protein Isolated from

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2020 Jun 4

PMID 32489302

Citations 2

Authors

Masoumeh Rezaei-Moshaei

Ali Bandehagh

Ali Dehestani

Ali Pakdin-Parizi

Majid Golkar

Affiliations

Soon will be listed here.

Abstract

Plant ribosome-inactivating proteins (RIPs) are N-glycosidases which inhibit protein synthesis through depurination of the ribosomal RNA sequence. Type II RIPs are heterodimer proteins which can bind to cell surfaces. The cytotoxicity of these RIPs is different. spp. are a rich source of RIP proteins with different properties. In the present study, a type II RIP was isolated from plant that grows widely in the north of Iran, and different bioinformatics tools were used for the evaluation of physicochemical, functional and 3D protein characteristics. The results showed significant differences among isolated RIP and other Sambucus RIP proteins. The study of these differences can not only expand our insight into the functioning mechanisms of plant RIPs but also provide information about a novel RIP protein with potential biological applications.

Citing Articles

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