Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

Overview

Journal Nutrients

Date 2020 Jun 4

PMID 32486525

Citations 4

Authors

Pamela A Nono Nankam

Paul J Van Jaarsveld

Elin Chorell

Melony C Fortuin-de Smidt

Kevin Adams

Matthias Bluher

Tommy Olsson

Amy E Mendham

Julia H Goedecke

Affiliations

Soon will be listed here.

Abstract

Methods: Participants' ( = 41) body fat composition and distribution, S, and RBC-TPL, abdominal and gluteal SAT (gSAT) FA composition (gas-liquid chromatography) were measured.

Results: RBC-TPL contained higher proportions of saturated fatty acids (SFAs) than SAT ( < 0.001), which were associated with lower S ( < 0.05). Mono-unsaturated fatty acids (MUFAs) and stearoyl-CoA desaturase-1 (SCD1)-16 were lower, while poly-unsaturated fatty acids (PUFAs), and delta-5 and delta-6 desaturase indices were higher in RBC-TPL than SAT ( < 0.001). Interestingly, FA profiles differed between SAT depots with higher SFAs and lower MUFAs, SCD1-16 and SCD1-18 indices in abdominal compared to gluteal SAT ( < 0.01). In both SAT depots, higher SFAs and lower PUFAs (n-3 and n-6) correlated with lower VAT/SAT ratio; and lower PUFAs (n-3 and n-6) and higher total MUFA correlated with higher S.

Conclusion: Our findings confirm the relationships between the FA composition of RBC-TPL and SAT and metabolic risk in black women with obesity, which are dependent on both the FA class, and the tissue type/blood compartment in which they are distributed.

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