Host Immunity to in Health and Disease

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2020 Jun 2

PMID 32477963

Citations 17

Authors

Florian Sparber

Fiorella Ruchti

Salome LeibundGut-Landmann

Affiliations

Soon will be listed here.

Abstract

The microbiota plays an integral role in shaping physical and functional aspects of the skin. While a healthy microbiota contributes to the maintenance of immune homeostasis, dysbiosis can result in the development of diverse skin pathologies. This dichotomous feature of the skin microbiota holds true not only for bacteria, but also for fungi that colonize the skin. As such, the yeast , which is by far the most abundant component of the skin mycobiota, is associated with a variety of skin disorders, of which some can be chronic and severe and have a significant impact on the quality of life of those affected. Understanding the causative relationship between and the development of such skin disorders requires in-depth knowledge of the mechanism by which the immune system interacts with and responds to the fungus. In this review, we will discuss recent advances in our understanding of the immune response to and how the implicated cells and cytokine pathways prevent uncontrolled fungal growth to maintain commensalism in the mammalian skin. We also review how the antifungal response is currently thought to affect the development and severity of inflammatory disorders of the skin and at distant sites.

Citing Articles

Malassezia Folliculitis: Pathogenesis and Diagnostic Challenges.

Martinez-Ortega J, Mut Quej J, Franco Gonzalez S Cureus. 2024; 16(11):e73429.

PMID: 39664138 PMC: 11633069. DOI: 10.7759/cureus.73429.

From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences.

Naik B, Sasikumar J, Das S Mol Neurobiol. 2024; 62(1):533-556.

PMID: 38871941 DOI: 10.1007/s12035-024-04270-w.

Regulatory Ability of on Human Skin Health by Counteracting In Vitro Effects.

Fusco A, Perfetto B, Savio V, Chiaromonte A, Torelli G, Donnarumma G J Fungi (Basel). 2023; 9(12).

PMID: 38132754 PMC: 10744525. DOI: 10.3390/jof9121153.

Impact of Exposomes on Ocular Surface Diseases.

Hong M, Tong L, Mehta J, Ong H Int J Mol Sci. 2023; 24(14).

PMID: 37511032 PMC: 10379833. DOI: 10.3390/ijms241411273.

Standardization of Galleria mellonella as an Infection Model for Malassezia furfur and Malassezia pachydermatis.

Torres M, Ramirez A Methods Mol Biol. 2023; 2667:15-29.

PMID: 37145273 DOI: 10.1007/978-1-0716-3199-7_2.

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