Alpha 2.0
Login Register
» Articles » PMID: 32471909

Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Overview
Journal Diabetes Care
Specialty Endocrinology
Date 2020 May 31
PMID 32471909
Citations 17
Authors
Jasna Suput Omladic
Anka Slana Ozimic
Andrej Vovk
Dusan Suput
Grega Repovs
Klemen Dovc
Natasa Bratina
Magdalena Avbelj Stefanija
Tadej Battelino
Affiliations
Soon will be listed here.
Abstract

Objective: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).

Research Design And Methods: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).

Results: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task ( = 0.014) were observed.

Conclusions: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.

Citing Articles

Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery.

Dovc K, Spanbauer C, Chiarle E, Bratina N, Frohlich-Reiterer E, Potocnik N Diabetes Obes Metab. 2025; 27(4):2147-2153.

PMID: 39868600 PMC: 11885092. DOI: 10.1111/dom.16211.

Continuous Glucose Monitoring-New Diagnostic Tool in Complex Pathophysiological Disorder of Glucose Metabolism in Children and Adolescents with Obesity.

Simunovic M, Kumric M, Rusic D, Paradzik Simunovic M, Bozic J Diagnostics (Basel). 2025; 14(24.

PMID: 39767162 PMC: 11674695. DOI: 10.3390/diagnostics14242801.

Prevalence and factors associated with school failure in children with type 1 diabetes.

Nouira S, Ach T, Ammar A, Ach M, Sabbagh G, Ezzi O Pediatr Endocrinol Diabetes Metab. 2024; 30(1):3-7.

PMID: 39026473 PMC: 11037087. DOI: 10.5114/pedm.2023.133124.

Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?.

Stanislawska-Kubiak M, Majewska K, Krasinska A, Wais P, Majewski D, Mojs E Ther Adv Chronic Dis. 2024; 15:20406223241229855.

PMID: 38560719 PMC: 10981223. DOI: 10.1177/20406223241229855.

Nasal Glucagon Reverses Insulin-induced Hypoglycemia With Less Rebound Hyperglycemia: Pooled Analysis of Clinical Trials.

Seaquist E, Gimenez M, Yan Y, Matsuhisa M, Kao C, Wadwa R J Endocr Soc. 2024; 8(4):bvae034.

PMID: 38444629 PMC: 10913376. DOI: 10.1210/jendso/bvae034.

References
1.
Malone J . Diabetic Central Neuropathy: CNS Damage Related to Hyperglycemia. Diabetes. 2016; 65(2):355-7. DOI: 10.2337/dbi15-0034. View
2.
Sommerfield A, Deary I, Frier B . Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care. 2004; 27(10):2335-40. DOI: 10.2337/diacare.27.10.2335. View
3.
Musen G, Tinsley L, Marcinkowski K, Pober D, Sun J, Khatri M . Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications. Diabetes Care. 2018; 41(8):1749-1756. PMC: 6054500. DOI: 10.2337/dc17-1955. View
4.
Libby L, Hannula D, Ranganath C . Medial temporal lobe coding of item and spatial information during relational binding in working memory. J Neurosci. 2014; 34(43):14233-42. PMC: 4205549. DOI: 10.1523/JNEUROSCI.0655-14.2014. View
5.
Cameron F, Northam E, Ryan C . The effect of type 1 diabetes on the developing brain. Lancet Child Adolesc Health. 2019; 3(6):427-436. DOI: 10.1016/S2352-4642(19)30055-0. View