Breast Cancer Prevention-Is There a Future for Sulforaphane and Its Analogs?

Overview

Journal Nutrients

Date 2020 May 31

PMID 32471217

Citations 16

Authors

Dominika Kuran

Anna Pogorzelska

Katarzyna Wiktorska

Affiliations

Soon will be listed here.

Abstract

Breast cancer is the most prevalent type of cancer among women worldwide. There are several recommended methods of breast cancer prevention, including chemoprevention. There are several approved drugs used to prevent breast cancer occurrence or recurrence and metastasizing. There are also a number of new substances undergoing clinical trials and at the stage of initial study. Studies suggest that dietary factors play a crucial role in breast cancer etiology. Epidemiological studies indicate that in particular vegetables from the family are a rich source of chemopreventive substances, with sulforaphane (SFN) being one of the most widely studied and characterized. This review discusses potential applicability of SFN in breast cancer chemoprevention. A comprehensive review of the literature on the impact of SFN on molecular signalling pathways in breast cancer and breast untransformed cells is presented. The presented results of in vitro and in vivo studies show that this molecule has a potential to act as a preventive molecule either to prevent disease development or recurrence and metastasizing, and as a compound protecting normal cells against the toxic effects of cytostatics. Finally, the still scanty attempts to develop an improved analog are also presented and discussed.

Citing Articles

Impact of Sulforaphane on Breast Cancer Progression and Radiation Therapy Outcomes: A Systematic Review.

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PMID: 40013196 PMC: 11863992. DOI: 10.7759/cureus.78060.

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Antitumor and antimetastatic effects of dietary sulforaphane in a triple-negative breast cancer models.

Pogorzelska A, Switalska M, Wietrzyk J, Mazur M, Milczarek M, Medynska K Sci Rep. 2024; 14(1):16016.

PMID: 38992004 PMC: 11239657. DOI: 10.1038/s41598-024-65455-w.

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies.

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