Association Between Serum Vitamin D Deficiency and Knee Osteoarthritis

Overview

Journal Mediterr J Rheumatol

Specialty Rheumatology

Date 2020 May 30

PMID 32467872

Citations 5

Authors

Hasan Anari

Afsaneh Enteshari-Moghaddam

Yeghaneh Abdolzadeh

Affiliations

Soon will be listed here.

Abstract

Objective: Levels of Vitamin D may influence the development of knee osteoarthritis (OA), which is one of the most common joint diseases. The aim of this study was to investigate the association between serum Vitamin D deficiency and knee OA in Ardabil and Iran.

Methods: One hundred fifty-eight consecutive patients referred to rheumatology clinic of Ardabil City Hospital were recruited in the study. All the participants underwent x-rays in two anterior-posterior and side views of the knees. Staging of knee OA was done according to Kellgren-Lawrence criteria. Seventy-nine individuals with clinical and radiographic signs of knee OA were defined as the case group, and those without clinical and radiographic signs of the disease were defined as a control group. Haematology and biochemical profile including measurement of 25-hydroxyvitamin D serum level was performed in the participants.

Results: The mean age of patients and controls were 54.12 ± 4.67 and 55.37 ± 5.12 years, respectively. The average serum vitamin D in OA patients and controls were 26.8±6.2 ng/ml and 28.1±5.3ng/ml, respectively (p=0.36). There was a significant association between serum vitamin D and staging of knee OA (p=0.001). Based on vitamin D levels, most of patients with vitamin D deficiency were in stages III and IV.

Conclusion: The findings of the study suggest that vitamin D deficiency should be considered in patients with OA and treated accordingly.

Citing Articles

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Association between vitamin D and knee osteoarthritis in Indian population: A systematic review and meta-analysis.

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L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study.

Xiao Q, Cai B, Yin A, Huo H, Lan K, Zhou G BMC Med. 2022; 20(1):308.

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