Diacylglycerol-evoked Activation of PKC and PKD Isoforms in Regulation of Glucose and Lipid Metabolism: a Review

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2020 May 30

PMID 32466765

Citations 55

Authors

Katarzyna Kolczynska

Angel Loza-Valdes

Izabela Hawro

Grzegorz Sumara

Affiliations

Soon will be listed here.

Abstract

Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.

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