Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2020 May 30

PMID 32466179

Citations 5

Authors

Ling-Sai Chang

Jia-Huei Yan

Jin-Yu Li

Deniz Des Yeter

Ying-Hsien Huang

Mindy Ming-Huey Guo

Mao-Hung Lo

Ho-Chang Kuo

Affiliations

Soon will be listed here.

Abstract

The risk of ethnic Kawasaki disease (KD) has been proposed to be associated with blood mercury levels in American children. We investigated the blood levels of mercury in children with KD and their association with disease outcome. The mercury levels demonstrated a significantly negative correlation with sodium levels ( = 0.007). However, data failed to reach a significant difference after excluding the child with blood mercury exceeding the toxic value. The findings indicate that KD patients with lower sodium concentrations had a remarkably higher proportion of intravenous immunoglobulin (IVIG) resistance ( = 0.022). Our patients who had lower mercury levels (<0.5 μg/L) had more changes in bacille Calmette-Guerin. Mercury levels in 14/14 patients with coronary artery lesions and 4/4 patients with IVIG resistance were all measured to have values greater than 1 μg/L (while average values showed 0.92 μg/L in Asian American children). Mercury levels had no correlations with IVIG resistance or coronary artery lesion (CAL) formation ( > 0.05). CAL development was more common in the incomplete group than in the complete KD group ( = 0.019). In this first report about mercury levels in KD patients, we observed that the juvenile Taiwanese had higher mercury concentration in blood compared to other populations.

Citing Articles

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children's Study (JECS).

Yanai T, Yoshida S, Takeuchi M, Kawakami C, Kawakami K, Ito S Sci Rep. 2024; 14(1):9947.

PMID: 38689029 PMC: 11061304. DOI: 10.1038/s41598-024-60830-z.

Combination of S100A12/TLR2 signaling molecules and clinical indicators in a new predictive model for IVIG-resistant Kawasaki disease.

Wu Y, Liu P, Zhou Y, Yang Y, Li S, Yin W Sci Rep. 2024; 14(1):7261.

PMID: 38538656 PMC: 10973373. DOI: 10.1038/s41598-024-57897-z.

Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease.

Wang W, Zhu L, Li X, Liu Z, Lv H, Qian G Front Microbiol. 2024; 14:1313838.

PMID: 38188572 PMC: 10771848. DOI: 10.3389/fmicb.2023.1313838.

[Association between duration of fever before treatment and intravenous immunoglobulin resistance in Kawasaki disease].

Wang X, Pan S, DU Z, Ji Z, Luo G, Sun H Zhongguo Dang Dai Er Ke Za Zhi. 2022; 24(4):399-404.

PMID: 35527415 PMC: 9044994. DOI: 10.7499/j.issn.1008-8830.2110137.

Desquamation in Kawasaki Disease.

Chang L, Weng K, Yan J, Lo W, Guo M, Huang Y Children (Basel). 2021; 8(5).

PMID: 33919412 PMC: 8143344. DOI: 10.3390/children8050317.

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