A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 May 28

PMID 32455975

Citations 10

Authors

Priscilla R Prestes

Michelle C Maier

Bradley A Woods

Fadi J Charchar

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension.

Citing Articles

Research trends and hotspots of circular RNA in cardiovascular disease: A bibliometric analysis.

Xu Z, Guan C, Cheng Z, Zhou H, Qin W, Feng J Noncoding RNA Res. 2024; 9(3):930-944.

PMID: 38680417 PMC: 11047193. DOI: 10.1016/j.ncrna.2024.04.002.

Alleviation of Angiotensin II-Induced Vascular Endothelial Cell Injury Through Long Non-coding RNA TUG1 Inhibition.

Shi L, Li H, Sun L, Tian C, Li H Comb Chem High Throughput Screen. 2023; 27(10):1523-1532.

PMID: 37818575 DOI: 10.2174/0113862073265220231004071645.

Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.

He S, Zhu H, Zhang J, Yang X, Zhao L Am J Transl Res. 2023; 15(7):4610-4619.

PMID: 37560213 PMC: 10408519.

Clinical Significance of MicroRNAs, Long Non-Coding RNAs, and CircRNAs in Cardiovascular Diseases.

Singh D, Kim Y, Choi S, Han I, Yadav D Cells. 2023; 12(12).

PMID: 37371099 PMC: 10297435. DOI: 10.3390/cells12121629.

CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension.

Liu C, Li N, Li F, Deng W, Dai G, Tang Y J Hum Hypertens. 2023; 37(11):1021-1027.

PMID: 37100987 DOI: 10.1038/s41371-023-00834-w.

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