The Relationship Between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers

Overview

Journal Pathogens

Date 2020 May 28

PMID 32455952

Citations 22

Authors

Claire D James

Iain M Morgan

Molly L Bristol

Affiliations

Soon will be listed here.

Abstract

High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to HPV-related cancers, although the exact nature of the interactions remains to be fully elucidated. Here we will focus on estrogen signaling and describe both pro and potentially anti-cancer effects of this hormone in HPV-positive cancers. This review will summarize: (1) cell culture-related evidence, (2) animal model evidence, and (3) clinical evidence demonstrating an interaction between estrogen and HPV-positive cancers. This comprehensive review provides insights into the potential relationship between estrogen and HPV. We suggest that estrogen may provide a potential therapeutic for HPV-related cancers, however additional studies are necessary.

Citing Articles

Treatment strategies in human papillomavirus-related advanced penile cancer.

Longoni M, Fankhauser C, Negri F, Salonia A, Basile G, Johnstone P Nat Rev Urol. 2025; .

PMID: 39966660 DOI: 10.1038/s41585-025-00994-z.

A comprehensive review on the potential of coumarin and related derivatives as multi-target therapeutic agents in the management of gynecological cancers.

Seker Karatoprak G, Dumlupinar B, Celep E, Kurt Celep I, Akkol E, Sobarzo-Sanchez E Front Pharmacol. 2024; 15:1423480.

PMID: 39364049 PMC: 11447453. DOI: 10.3389/fphar.2024.1423480.

Analysis of Expression and Regulation of AKR1C2 in HPV-Positive and -Negative Oropharyngeal Squamous Cell Carcinoma.

Ziogas M, Siefer O, Wuerdemann N, Balaji H, Gross E, Drebber U Cancers (Basel). 2024; 16(17).

PMID: 39272833 PMC: 11394552. DOI: 10.3390/cancers16172976.

Fibroblast stromal support model for predicting human papillomavirus-associated cancer drug responses.

James C, Lewis R, Fakunmoju A, Witt A, Youssef A, Wang X J Virol. 2024; 98(10):e0102424.

PMID: 39269177 PMC: 11494926. DOI: 10.1128/jvi.01024-24.

Therapeutic Role of HPV Vaccination on Benign HPV-induced Epithelial Proliferations in Immunocompetent and Immunocompromised Patients: Case Study and Review of the Literature.

Matucci-Cerinic C, Herzum A, Ciccarese G, Rosina S, Caorsi R, Gattorno M Open Forum Infect Dis. 2024; 11(7):ofae369.

PMID: 39035570 PMC: 11259138. DOI: 10.1093/ofid/ofae369.

References

Rudraraju B, Droog M, Abdel-Fatah T, Zwart W, Giannoudis A, Malki M . Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer. Breast Cancer Res Treat. 2014; 147(2):295-309. DOI: 10.1007/s10549-014-3098-0. View

Mitrani-Rosenbaum S, Tsvieli R, Tur-Kaspa R . Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical carcinoma cells. J Gen Virol. 1989; 70 ( Pt 8):2227-32. DOI: 10.1099/0022-1317-70-8-2227. View

Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F . Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017; 174:96-113. DOI: 10.1016/j.jsbmb.2017.08.003. View

McPhillips M, Oliveira J, Spindler J, Mitra R, McBride A . Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J Virol. 2006; 80(19):9530-43. PMC: 1617221. DOI: 10.1128/JVI.01105-06. View

Simpson E . Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003; 86(3-5):225-30. DOI: 10.1016/s0960-0760(03)00360-1. View

Cauley J . Estrogen and bone health in men and women. Steroids. 2015; 99(Pt A):11-5. DOI: 10.1016/j.steroids.2014.12.010. View

Li D, Chen J, Ai Y, Gu X, Li L, Che D . Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol Cell. 2019; 75(6):1103-1116.e9. DOI: 10.1016/j.molcel.2019.06.040. View

McLaughlin-Drubin M, Munger K . Oncogenic activities of human papillomaviruses. Virus Res. 2009; 143(2):195-208. PMC: 2730997. DOI: 10.1016/j.virusres.2009.06.008. View

Graham S . The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clin Sci (Lond). 2017; 131(17):2201-2221. DOI: 10.1042/CS20160786. View

10.

Cannarella R, Condorelli R, Mongioi L, Barbagallo F, Calogero A, La Vignera S . Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis. Expert Opin Pharmacother. 2019; 20(12):1517-1525. DOI: 10.1080/14656566.2019.1615057. View

11.

Samir R, Asplund A, Tot T, Pekar G, Hellberg D . High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a. J Low Genit Tract Dis. 2011; 15(4):280-6. DOI: 10.1097/LGT.0b013e318215170c. View

12.

Bourguignon L, Gilad E, Rothman K, Peyrollier K . Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. J Biol Chem. 2005; 280(12):11961-72. DOI: 10.1074/jbc.M411985200. View

13.

Brianti P, De Flammineis E, Mercuri S . Review of HPV-related diseases and cancers. New Microbiol. 2017; 40(2):80-85. View

14.

Taneja V . Sex Hormones Determine Immune Response. Front Immunol. 2018; 9:1931. PMC: 6119719. DOI: 10.3389/fimmu.2018.01931. View

15.

Li S, Xie L, Du M, Xu K, Zhu L, Chu H . Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival. Arch Toxicol. 2018; 92(6):1991-1999. DOI: 10.1007/s00204-018-2195-y. View

16.

Stunkel W, Bernard H . The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression. J Virol. 1999; 73(3):1918-30. PMC: 104433. DOI: 10.1128/JVI.73.3.1918-1930.1999. View

17.

Hong S, Laimins L . Regulation of the life cycle of HPVs by differentiation and the DNA damage response. Future Microbiol. 2013; 8(12):1547-57. PMC: 3951404. DOI: 10.2217/fmb.13.127. View

18.

Peter M, Rosty C, Couturier J, Radvanyi F, Teshima H, Sastre-Garau X . MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors. Oncogene. 2006; 25(44):5985-93. DOI: 10.1038/sj.onc.1209625. View

19.

Fuentes N, Silveyra P . Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019; 116:135-170. PMC: 6533072. DOI: 10.1016/bs.apcsb.2019.01.001. View

20.

Yim E, Park J . The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis. Cancer Res Treat. 2009; 37(6):319-24. PMC: 2785934. DOI: 10.4143/crt.2005.37.6.319. View