Enriched LPS Staining Within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2020 May 27

PMID 32455142

Citations 2

Authors

Lei Huang

Jianning Deng

Ren Lang

Guoyang Liao

Wei Jiang

Affiliations

Soon will be listed here.

Abstract

An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. We found enriched bacterial LPS immunohistochemistry staining in the germinal center of a lymph node from an HIV-infected LTNP, evenly distributed from three progressors with impaired germinal center structures and rarely detected from two HIV-negative individuals. The impaired germinal center structures were consistent with collagen deposition in lymph nodes using immunohistochemistry staining. These results suggest greater immune responses against bacterial LPS translocation in LTNPs, which may reveal an important mechanism in controlling microbial translocation and disease progression in HIV LTNPs.

Citing Articles

Exposure to Secreted Bacterial Factors Promotes HIV-1 Replication in CD4 T Cells.

Znaidia M, de Souza-Angelo Y, Letoffe S, Staropoli I, Grzelak L, Ghigo J Microbiol Spectr. 2023; 11(2):e0431322.

PMID: 36853052 PMC: 10100953. DOI: 10.1128/spectrum.04313-22.

Lv T, Cao W, Li T J Immunol Res. 2021; 2021:7316456.

PMID: 34631899 PMC: 8494587. DOI: 10.1155/2021/7316456.

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