» Articles » PMID: 32455042

Alveolar Echinococcosis in Children

Overview
Publisher Wiley
Specialty Pediatrics
Date 2020 May 27
PMID 32455042
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

Alveolar echinococcosis (AE) is an infectious zoonotic disease that is caused by . The disease is generally identified accidentally because of the long asymptomatic period, has a malignant behaviour, and mainly occurs in the liver. Usually it is diagnosed in adults and is very rare in pediatric patients. We report two cases of AE and 1 differential case between AE and cystic echinococcosis (CE) in children: two of them had lesions in the liver and one had rare extrahepatic presentation of a cyst in the spleen. All our patients received chemotherapy with albendazole because surgical treatment was not recommended. The children were followed-up from 10 to 30 months and no significant improvement was seen. In this report we discuss the difficulties we faced in the treatment and follow-up of these patients. We also review the main clinical manifestations, general diagnostic methods, and treatment options of AE according to the current literature.

Citing Articles

Young Age of Alveolar Echinococcosis Patient in Armenia: A Case Report.

Manukyan A Iran J Parasitol. 2024; 18(4):568-572.

PMID: 38169610 PMC: 10758085. DOI: 10.18502/ijpa.v18i4.14266.


Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations.

Hager J, Sergi C Diagnostics (Basel). 2023; 13(7).

PMID: 37046561 PMC: 10093495. DOI: 10.3390/diagnostics13071343.

References
1.
Nahorski W, Knap J, Pawlowski Z, Krawczyk M, Polanski J, Stefaniak J . Human alveolar echinococcosis in Poland: 1990-2011. PLoS Negl Trop Dis. 2013; 7(1):e1986. PMC: 3536814. DOI: 10.1371/journal.pntd.0001986. View

2.
Kern P, Bardonnet K, Renner E, Auer H, Pawlowski Z, Ammann R . European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000. Emerg Infect Dis. 2003; 9(3):343-9. PMC: 2958541. DOI: 10.3201/eid0903.020341. View

3.
Wang J, Jebbawi F, Bellanger A, Beldi G, Millon L, Gottstein B . Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. Parasite Immunol. 2018; 40(12):e12596. PMC: 6587932. DOI: 10.1111/pim.12596. View

4.
Cheng Z, Liu F, Tian H, Xu Z, Chai X, Luo D . Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase. PLoS Negl Trop Dis. 2019; 13(5):e0007425. PMC: 6541280. DOI: 10.1371/journal.pntd.0007425. View

5.
Horton J . Albendazole for the treatment of echinococcosis. Fundam Clin Pharmacol. 2003; 17(2):205-12. DOI: 10.1046/j.1472-8206.2003.00171.x. View