Argonaute Proteins: Structural Features, Functions and Emerging Roles

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2020 May 27

PMID 32455006

Citations 48

Authors

Jinen Wu

Jing Yang

William C Cho

Yadong Zheng

Affiliations

Soon will be listed here.

Abstract

Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing pathways. As a key player in these pathways, the abnormal expression and/or mis-modifications of Argonaute proteins lead to the disorder of small RNA biogenesis and functions, thus influencing multiply biological processes and disease development, especially cancer. In this review, we focus on the post-translational modifications and novel functions of Argonaute proteins in alternative splicing, host defense and genome editing.

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