Chromosome-Level Clam Genome Helps Elucidate the Molecular Basis of Adaptation to a Buried Lifestyle

Overview

Journal iScience

Publisher Cell Press

Date 2020 May 27

PMID 32454450

Citations 12

Authors

Min Wei

Hongxing Ge

Changwei Shao

Xiwu Yan

Hongtao Nie

Haibao Duan

Xiaoting Liao

Min Zhang

Yihua Chen

Dongdong Zhang

Zhiguo Dong

Affiliations

Soon will be listed here.

Abstract

Bivalve mollusks are economically important invertebrates that exhibit marked diversity in benthic lifestyle and provide valuable resources for understanding the molecular basis of adaptation to benthic life. In this report, we present a high-quality, chromosome-anchored reference genome of the Venus clam, Cyclina sinensis. The chromosome-level genome was assembled by Pacific Bioscience single-molecule real-time sequencing, Illumina paired-end sequencing, 10× Genomics, and high-throughput chromosome conformation capture technologies. The final genome assembly of C. sinensis is 903.2 Mb in size, with a contig N50 size of 2.6 Mb and a scaffold N50 size of 46.5 Mb. Enrichment analyses of significantly expanded and positively selected genes suggested evolutionary adaptation of this clam to buried life. In addition, a change in shell color represents another mechanism of adaptation to burial in sediment. The high-quality genome generated in this work provides a valuable resource for investigating the molecular mechanisms of adaptation to buried lifestyle.

Citing Articles

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Law S, Nong W, Au M, Cheung L, Shum C, Lee S Sci Data. 2025; 12(1):409.

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