Dependence Between Estrogen Sulfotransferase (SULT1E1) and Nuclear Transcription Factor Nrf-2 Regulations Via Oxidative Stress in Breast Cancer

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2020 May 26

PMID 32449069

Citations 4

Authors

Aarifa Nazmeen

Guangping Chen

Smarajit Maiti

Affiliations

Soon will be listed here.

Abstract

Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression influences each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and post-menopausal women remains to be connected with post-menopausal breast cancer. A synergism between ROS production and E2 generation has been demonstrated. No definite mechanism for simultaneous functions of Nrf2, oxidative stress E2 regulating enzymes (SULT1E1) has been yet clarified. Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. This study also focuses the idea that estrogen receptor cased subtypes of cancer may have different molecular environments which has an impact on the therapeutic efficacy.

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References

Motohashi H, Yamamoto M . Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med. 2004; 10(11):549-57. DOI: 10.1016/j.molmed.2004.09.003. View

Klaassen C, Slitt A . Regulation of hepatic transporters by xenobiotic receptors. Curr Drug Metab. 2005; 6(4):309-28. DOI: 10.2174/1389200054633826. View

Mandlekar S, Hong J, Kong A . Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects. Curr Drug Metab. 2006; 7(6):661-75. DOI: 10.2174/138920006778017795. View

Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin J, Friedman E, Slingerland J . Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017; 67(5):378-397. PMC: 5591063. DOI: 10.3322/caac.21405. View

Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X . Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers. Cancer Sci. 2012; 103(6):1000-9. PMC: 7685083. DOI: 10.1111/j.1349-7006.2012.02258.x. View

Maiti S, Nazmeen A . Impaired redox regulation of estrogen metabolizing proteins is important determinant of human breast cancers. Cancer Cell Int. 2019; 19:111. PMC: 6518504. DOI: 10.1186/s12935-019-0826-x. View

Guo Y, Hu B, Huang H, Tsung A, Gaikwad N, Xu M . Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury. J Biol Chem. 2015; 290(23):14754-64. PMC: 4505540. DOI: 10.1074/jbc.M115.642124. View

Chen G, Yin S, Maiti S, Shao X . 4-Hydroxytamoxifen sulfation metabolism. J Biochem Mol Toxicol. 2002; 16(6):279-85. DOI: 10.1002/jbt.10048. View

Maiti S, Chen G . Methotrexate is a novel inducer of rat liver and intestinal sulfotransferases. Arch Biochem Biophys. 2003; 418(2):161-8. DOI: 10.1016/j.abb.2003.08.019. View

10.

Maiti S, Chen G . Ethanol up-regulates phenol sulfotransferase (SULT1A1) and hydroxysteroid sulfotransferase (SULT2A1) in rat liver and intestine. Arch Physiol Biochem. 2015; 121(2):68-74. DOI: 10.3109/13813455.2014.992440. View

11.

Maiti S, Chen X, Chen G . All-trans retinoic acid induction of sulfotransferases. Basic Clin Pharmacol Toxicol. 2005; 96(1):44-53. DOI: 10.1111/j.1742-7843.2005.pto960107.x. View

12.

Sajadimajd S, Khazaei M . Oxidative Stress and Cancer: The Role of Nrf2. Curr Cancer Drug Targets. 2017; 18(6):538-557. DOI: 10.2174/1568009617666171002144228. View

13.

Zorov D, Juhaszova M, Sollott S . Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014; 94(3):909-50. PMC: 4101632. DOI: 10.1152/physrev.00026.2013. View

14.

Brown N, Bicknell R . Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res. 2001; 3(5):323-7. PMC: 138696. DOI: 10.1186/bcr315. View

15.

Schieber M, Chandel N . ROS function in redox signaling and oxidative stress. Curr Biol. 2014; 24(10):R453-62. PMC: 4055301. DOI: 10.1016/j.cub.2014.03.034. View

16.

Maiti S, Zhang J, Chen G . Redox regulation of human estrogen sulfotransferase (hSULT1E1). Biochem Pharmacol. 2007; 73(9):1474-81. PMC: 1950446. DOI: 10.1016/j.bcp.2006.12.026. View

17.

Nazmeen A, Maiti S . Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations. Mol Biol Rep. 2018; 45(6):2571-2584. DOI: 10.1007/s11033-018-4425-z. View

19.

Li W, Kong A . Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog. 2008; 48(2):91-104. PMC: 2631094. DOI: 10.1002/mc.20465. View

20.

Liu W, Ye L, Huang W, Guo L, Xu Z, Wu H . p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell Mol Biol Lett. 2017; 21:29. PMC: 5415757. DOI: 10.1186/s11658-016-0031-z. View

21.

Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T . Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007; 131(6):1149-63. DOI: 10.1016/j.cell.2007.10.035. View