Comparison of Myocardial Blood Flow and Flow Reserve with Dobutamine and Dipyridamole Stress Using Rubidium-82 Positron Emission Tomography

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2020 May 26

PMID 32449001

Citations 2

Authors

Matthieu Pelletier-Galarneau

Paola Ferro

Samuel Patterson

Terrence D Ruddy

Rob S Beanlands

Robert A deKemp

Affiliations

Soon will be listed here.

Abstract

Background: The objective of this study was to compare the hyperemic myocardial blood flow (MBF) and myocardial flow reserve (MFR) obtained with dobutamine to those of dipyridamole in patients referred for myocardial perfusion imaging (MPI) using Rb positron emission tomography.

Methods: One hundred and fifty-six patients who underwent a Rb PET MPI study with dobutamine stress were included. A matching cohort of patients who underwent a Rb PET MPI study with dipyridamole stress was created, accounting for sex, age, history of coronary artery disease (CAD), prior revascularization, CAD risk factors, body mass index, and MPI interpretation.

Results: Global rest MBF (median [interquartile range] 0.84 [0.64-1.00] vs 0.69 [0.59-0.85]), stress MBF (2.36 [1.73-3.08] vs 1.66 [1.25-2.06]), MFR (2.75 [2.19-3.64] vs 2.29 [1.78-2.84]), and corrected MFR (2.85 [2.14-3.64] vs 2.20 [1.65-2.75]) were all significantly higher (P < 0.0001) in the dobutamine cohort compared to the dipyridamole cohort.

Conclusion: The results of this study suggest that dobutamine produces higher MBF compared to dipyridamole in a representative population referred to nuclear cardiology laboratories.

Citing Articles

Comparative Analysis of the Feasibility of Myocardial Blood Flow Index Versus CT-FFR in the Diagnosis of Suspected Coronary Artery Disease.

Xiong Q, Fu X, Chen Y, Zheng Y, Wang L, Zhang W Rev Cardiovasc Med. 2024; 25(8):284.

PMID: 39228505 PMC: 11367003. DOI: 10.31083/j.rcm2508284.

A preliminary study of dobutamine myocardial flow reserve on Tc-Sestamibi CZT-SPECT.

Yan M, Shang H, Hao L, Guo X, Zheng H, Li H Ann Nucl Med. 2023; 37(6):349-359.

PMID: 36892730 DOI: 10.1007/s12149-023-01829-w.

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