Stem Cell Therapy: a Potential Approach for Treatment of Influenza Virus and Coronavirus-induced Acute Lung Injury

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2020 May 26

PMID 32448377

Citations 31

Authors

Jiang Du

Han Li

Jie Lian

Xinxing Zhu

Liang Qiao

Juntang Lin

Affiliations

Soon will be listed here.

Abstract

Acute lung injury (ALI), an increasingly devastating human disorder, is characterized by a multitude of lung changes arising from a wide variety of lung injuries. Viral infection is the main cause of morbidity and mortality in ALI and acute respiratory distress syndrome (ARDS) patients. In particular, influenza virus, coronavirus, and other respiratory viruses circulate in nature in various animal species and can cause severe and rapidly spread human infections. Although scientific advancements have allowed for rapid progress to be made to understand the pathogenesis and develop therapeutics after each viral pandemic, few effective methods to treat virus-induced ALI have been described. Recently, stem cell therapy has been widely used in the treatment of various diseases, including ALI. In this review, we detail the present stem cell-based therapeutics for lung injury caused by influenza virus and the outlook for the future state of stem cell therapy to deal with emerging influenza and coronaviruses.

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