New Antimicrobial and Cytotoxic Benzofuran Glucoside from L

The ethyl acetate fraction of the dried aerial parts of L. exhibited significant antimicrobial activity against some of selected bacteria and fungi. Also, it showed potent cytotoxicity against PANC-1 cancer cell lines under glucose deficient medium. The ethyl acetate fraction was subjected to different chromatographic techniques for isolation of the bioactive compounds. A new benzofuran glucoside; 2,3-dihydro-3-hydroxyeuparin 3-O-glucopyranoside () was isolated. Additionally, two known flavonoid compounds isorhamentin 3-O--D-glucoside (), and isorhamentin 3-O--D-rutinoside () were first identified in . Compound exhibited potent antimicrobial activities against two Gram-positive bacteria, one Gram-negative bacteria, and two fungi. Also, it displayed potent cytotoxic activity against PANC-1 cancer cell lines under glucose deficient medium (IC50 7.5 μM). However, the isolated flavonoid glycosides ( & ) showed moderate antimicrobial activities against two Gram-positive bacteria, two Gram-negative bacteria, four fungi, and did not show any cytotoxic activity against PANC-1.