NF-κB Signaling in Tanycytes Mediates Inflammation-induced Anorexia

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2020 May 25

PMID 32446877

Citations 15

Authors

Mareike Bottcher

Helge Muller-Fielitz

Sivaraj M Sundaram

Sarah Gallet

Vanessa Neve

Kiseko Shionoya

Adriano Zager

Ning Quan

Xiaoyu Liu

Ruth Schmidt-Ullrich

Ronny Haenold

Jan Wenzel

Anders Blomqvist

David Engblom

Vincent Prevot

Markus Schwaninger

Affiliations

Soon will be listed here.

Abstract

Objectives: Infections, cancer, and systemic inflammation elicit anorexia. Despite the medical significance of this phenomenon, the question of how peripheral inflammatory mediators affect the central regulation of food intake is incompletely understood. Therefore, we have investigated the sickness behavior induced by the prototypical inflammatory mediator IL-1β.

Methods: IL-1β was injected intravenously. To interfere with IL-1β signaling, we deleted the essential modulator of NF-κB signaling (Nemo) in astrocytes and tanycytes.

Results: Systemic IL-1β increased the activity of the transcription factor NF-κB in tanycytes of the mediobasal hypothalamus (MBH). By activating NF-κB signaling, IL-1β induced the expression of cyclooxygenase-2 (Cox-2) and stimulated the release of the anorexigenic prostaglandin E (PGE) from tanycytes. When we deleted Nemo in astrocytes and tanycytes, the IL-1β-induced anorexia was alleviated whereas the fever response and lethargy response were unchanged. Similar results were obtained after the selective deletion of Nemo exclusively in tanycytes.

Conclusions: Tanycytes form the brain barrier that mediates the anorexic effect of systemic inflammation in the hypothalamus.

Citing Articles

Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling.

Nemeth D, Liu X, Monet M, Niu H, Maxey G, Schrier M J Neuroinflammation. 2024; 21(1):303.

PMID: 39563437 PMC: 11575132. DOI: 10.1186/s12974-024-03287-1.

Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes.

Brunner M, Lopez-Rodriguez D, Estrada-Meza J, Dali R, Rohrbach A, Deglise T Nat Commun. 2024; 15(1):6604.

PMID: 39098920 PMC: 11298547. DOI: 10.1038/s41467-024-50913-w.

Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism.

Fernandois D, Rusidze M, Mueller-Fielitz H, Sauve F, Deligia E, Silva M Metabolism. 2024; 158:155976.

PMID: 39019342 PMC: 7616427. DOI: 10.1016/j.metabol.2024.155976.

Obesity-induced inflammation: connecting the periphery to the brain.

Le Thuc O, Garcia-Caceres C Nat Metab. 2024; 6(7):1237-1252.

PMID: 38997442 DOI: 10.1038/s42255-024-01079-8.

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease.

Qi G, Tang H, Hu J, Kang S, Qin S Neural Regen Res. 2024; 20(6):1599-1612.

PMID: 38934388 PMC: 11688558. DOI: 10.4103/NRR.NRR-D-23-01865.

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