Drug/polymer Matrix Swelling and Dissolution

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 1988 Aug 1

PMID 3244656

Citations 34

Authors

R S Harland

A Gazzaniga

M E Sangalli

P Colombo

N A Peppas

Affiliations

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Abstract

The swelling and dissolution behavior of pharmaceutical systems containing a drug and a polymer can be analyzed by a mathematical model which predicts the drug released and the gel layer thickness as a function of time. It is possible to approximate the values of several of the physicochemical parameters of this model in order to obtain an order-of-magnitude analysis of the tablet dissolution process. Selected experimental results of tablet dissolution and drug release are analyzed and conclusions are made about the importance of the drug and polymer content and solubility in the release behavior.

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