Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function

Overview

Journal J Neuroimmune Pharmacol

Specialties Allergy & Immunology
Neurology
Pharmacology

Date 2020 May 24

PMID 32445005

Citations 8

Authors

Sheri L Towe

Christina S Meade

Christine C Cloak

Ryan P Bell

Julian Baptiste

Linda Chang

Affiliations

Soon will be listed here.

Abstract

Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.

Citing Articles

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References

Copeland J, Pokorski I . Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review. Subst Abuse Rehabil. 2016; 7:41-53. PMC: 4862355. DOI: 10.2147/SAR.S89857. View

Mechoulam R, Parker L . The endocannabinoid system and the brain. Annu Rev Psychol. 2012; 64:21-47. DOI: 10.1146/annurev-psych-113011-143739. View

Crane H, McCaul M, Chander G, Hutton H, Nance R, Delaney J . Prevalence and Factors Associated with Hazardous Alcohol Use Among Persons Living with HIV Across the US in the Current Era of Antiretroviral Treatment. AIDS Behav. 2017; 21(7):1914-1925. PMC: 5628735. DOI: 10.1007/s10461-017-1740-7. View

Haney M, Gunderson E, Rabkin J, Hart C, Vosburg S, Comer S . Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep. J Acquir Immune Defic Syndr. 2007; 45(5):545-54. DOI: 10.1097/QAI.0b013e31811ed205. View

Fogarty A, Rawstorne P, Prestage G, Crawford J, Grierson J, Kippax S . Marijuana as therapy for people living with HIV/AIDS: social and health aspects. AIDS Care. 2007; 19(2):295-301. DOI: 10.1080/09540120600841930. View

Colizzi M, McGuire P, Pertwee R, Bhattacharyya S . Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence. Neurosci Biobehav Rev. 2016; 64:359-81. DOI: 10.1016/j.neubiorev.2016.03.010. View

Skalski L, Towe S, Sikkema K, Meade C . The Impact of Marijuana Use on Memory in HIV-Infected Patients: A Comprehensive Review of the HIV and Marijuana Literatures. Curr Drug Abuse Rev. 2016; 9(2):126-141. PMC: 5093083. DOI: 10.2174/1874473709666160502124503. View

Chang L, Yakupov R, Cloak C, Ernst T . Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain. 2006; 129(Pt 5):1096-112. DOI: 10.1093/brain/awl064. View

Xu C, Hermes D, Nwanguma B, Jacobs I, Mackie K, Mukhopadhyay S . Endocannabinoids exert CB receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein. Mol Cell Neurosci. 2017; 83:92-102. PMC: 5587778. DOI: 10.1016/j.mcn.2017.07.003. View

10.

Araque A, Castillo P, Manzoni O, Tonini R . Synaptic functions of endocannabinoid signaling in health and disease. Neuropharmacology. 2017; 124:13-24. PMC: 5662005. DOI: 10.1016/j.neuropharm.2017.06.017. View

11.

Solowij N, Battisti R . The chronic effects of cannabis on memory in humans: a review. Curr Drug Abuse Rev. 2009; 1(1):81-98. DOI: 10.2174/1874473710801010081. View

12.

Srivastava M, Srivastava B, Brouhard B . Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology. 1998; 40(3):179-85. DOI: 10.1016/s0162-3109(98)00041-1. View

13.

Chang L, Shukla D . Imaging studies of the HIV-infected brain. Handb Clin Neurol. 2018; 152:229-264. DOI: 10.1016/B978-0-444-63849-6.00018-9. View

14.

Zhang X, Thayer S . Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling. Neuropharmacology. 2017; 128:269-281. PMC: 5752128. DOI: 10.1016/j.neuropharm.2017.10.023. View

15.

Ernst T, Jiang C, Nakama H, Buchthal S, Chang L . Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorder. J Magn Reson Imaging. 2010; 32(5):1045-53. PMC: 2967445. DOI: 10.1002/jmri.22366. View

16.

Avraham H, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Wood J . Impaired neurogenesis by HIV-1-Gp120 is rescued by genetic deletion of fatty acid amide hydrolase enzyme. Br J Pharmacol. 2014; 172(19):4603-14. PMC: 4594266. DOI: 10.1111/bph.12657. View

17.

Dager A, Tice M, Book G, Tennen H, Raskin S, Austad C . Relationship between fMRI response during a nonverbal memory task and marijuana use in college students. Drug Alcohol Depend. 2018; 188:71-78. PMC: 6756147. DOI: 10.1016/j.drugalcdep.2018.03.025. View

18.

Cattie J, Doyle K, Weber E, Grant I, Woods S . Planning deficits in HIV-associated neurocognitive disorders: component processes, cognitive correlates, and implications for everyday functioning. J Clin Exp Neuropsychol. 2012; 34(9):906-18. PMC: 3460068. DOI: 10.1080/13803395.2012.692772. View

19.

Broyd S, van Hell H, Beale C, Yucel M, Solowij N . Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic Review. Biol Psychiatry. 2016; 79(7):557-67. DOI: 10.1016/j.biopsych.2015.12.002. View

20.

Sneider J, Mashhoon Y, Silveri M . A Review of Magnetic Resonance Spectroscopy Studies in Marijuana using Adolescents and Adults. J Addict Res Ther. 2014; Suppl 4. PMC: 3936252. DOI: 10.4172/2155-6105.S4-010. View