Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach

Overview

Journal Children (Basel)

Specialty Health Services

Date 2020 May 24

PMID 32443418

Citations 4

Authors

Giorgio Ciprandi

Gian Luigi Marseglia

Fabio Luigi Massimo Ricciardolo

Maria Angela Tosca

Affiliations

Soon will be listed here.

Abstract

Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Biomarkers are necessary for defining phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are experimental and/or not commonly available. The current paper will, therefore, present pragmatic biomarkers useful for asthma management that are available in daily clinical practice. In this regard, eosinophil assessment and serum allergen-specific IgE assay are the most reliable biomarkers. Lung function, mainly concerning forced expiratory flow at 25-755 of vital capacity (FEF), and nasal cytology may be envisaged as ancillary biomarkers in asthma management. In conclusion, biomarkers have clinical relevance in asthma concerning both the endotype definition and the personalization of the therapy.

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