Hydrogel Production Platform with Dynamic Movement Using Photo-Crosslinkable/Temperature Reversible Chitosan Polymer and Stereolithography 4D Printing Technology

Overview

Journal Tissue Eng Regen Med

Date 2020 May 23

PMID 32441008

Citations 14

Authors

Jeong Wook Seo

Su Ryon Shin

Yeon Joo Park

Hojae Bae

Affiliations

Soon will be listed here.

Abstract

Background: Three-dimensional (3D) printing using hydrogel has made great strides when it comes to mimicking 3D artificial tissue in the medical field. However, most structures do not mimic the dynamic movement of the tissues. Without imitating dynamic movements, there are limitations on the extent to which the proper implementation of the tissue's own functions can be achieved.

Method: In this study, we intend to present an approach to solving this problem using hydroxybutyl methacrylated chitosan (HBC-MA), a photo-crosslinkable/temperature reversible chitosan polymer. In addition, stereolithography-3D (SLA-3D) printing technology was used, which is more likely to mimic the complex microstructure. As a control, a 3D structure made with pristine poly(ethylene glycol) dimethacrylate (PEG-DMA) was created, and a 4D structure was prepared by adding HBC-MA to poly(ethylene glycol) dimethacrylate (PEG-DMAP) resin.

Results: HBC-MA caused the expansion of water into the polymer matrix at low temperature, and the 4D structure resulted in expansion of the polymer volume, generating dynamic movement due to the expansion of water. Conversely, as the temperature rose, deswelling occurred, followed by a decrease in the volume, showing a shape memory property of returning to the existing structure. Morphological, swelling, and mechanical analysis further confirmed the principle of dynamic movement. In addition, parameters were provided through calculation of the bending ratio angle (θ).

Conclusion: Through this, it is suggested that HBC-MA can be applied as a core polymer for SLA-4D printing, and has high potential for realizing the dynamic movement of tissue.

Citing Articles

Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications.

Timofticiuc I, Calinescu O, Iftime A, Dragosloveanu S, Caruntu A, Scheau A J Funct Biomater. 2024; 15(1).

PMID: 38248674 PMC: 10816811. DOI: 10.3390/jfb15010007.

3D-Printed Hydrogel for Diverse Applications: A Review.

Agrawal A, Hussain C Gels. 2023; 9(12).

PMID: 38131946 PMC: 10743314. DOI: 10.3390/gels9120960.

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications.

Taokaew S, Kaewkong W, Kriangkrai W Gels. 2023; 9(4).

PMID: 37102889 PMC: 10138304. DOI: 10.3390/gels9040277.

Improving Printability of Digital-Light-Processing 3D Bioprinting via Photoabsorber Pigment Adjustment.

Seo J, Kim G, Choi Y, Cha J, Bae H Int J Mol Sci. 2022; 23(10).

PMID: 35628238 PMC: 9143265. DOI: 10.3390/ijms23105428.

The 3D Bioprinted Scaffolds for Wound Healing.

Edmundo Antezana P, Municoy S, Alvarez-Echazu M, Santo-Orihuela P, Catalano P, Al-Tel T Pharmaceutics. 2022; 14(2).

PMID: 35214197 PMC: 8875365. DOI: 10.3390/pharmaceutics14020464.

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