Childhood Central Nervous System Tumors and Leukemia: Incidence and Familial Risk. A Comparative Population-based Study in Utah and Norway

Overview

Journal Pediatr Blood Cancer

Specialties Hematology
Oncology
Pediatrics

Date 2020 May 22

PMID 32437093

Citations 1

Authors

Ruby Del Risco Kollerud

Lisa A Cannon-Albright

Hege S Haugnes

Ellen Ruud

Magne Thoresen

Per Nafstad

Karl Gerhard Blaasaas

Oyvind Naess

Bjorgulf Claussen

Affiliations

Soon will be listed here.

Abstract

Background: In this study, we aimed to evaluate incidence rates and family risk of the most common childhood cancers, tumors in the central nervous system (CNS), and leukemia among individuals from Norway and individuals with Scandinavian ancestry living in Utah.

Methods: We used the Utah Population Database and the Norwegian National Population Register linked to Cancer registries to identify cancers in children born between 1966 and 2015 and their first-degree relatives. We calculated incidence rates and hazards ratios.

Results: The overall incidence of CNS tumors increased with consecutive birth cohorts similarly in Utah and Norway (both P < 0.001). Incidence rates of leukemia were more stable and similar in both Utah and in Norway with 4.6/100 000 person-years among children (<15 years) born in the last cohort. A family history of CNS tumors was significantly associated with risk of childhood CNS tumors in Utah HR = 3.05 (95% CI 1.80-5.16) and Norway HR = 2.87 (95% CI 2.20-3.74). In Norway, children with a first-degree relative diagnosed with leukemia had high risk of leukemia (HR = 2.39, 95% CI 1.61-3.55).

Conclusion: Despite geographical distance and assumed large lifestyle differences, two genetically linked pediatric populations show similar incidences of CNS tumors and leukemia in the period 1966-2015. CNS tumors and leukemia aggregated in families in both countries.

Citing Articles

CBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.

Ostrom Q, Price M, Ryan K, Edelson J, Neff C, Cioffi G Neuro Oncol. 2022; 24(Suppl 3):iii1-iii38.

PMID: 36066969 PMC: 9447434. DOI: 10.1093/neuonc/noac161.

References

Barrington-Trimis J, Cockburn M, Metayer C, Gauderman W, Wiemels J, McKean-Cowdin R . Trends in childhood leukemia incidence over two decades from 1992 to 2013. Int J Cancer. 2016; 140(5):1000-1008. PMC: 5550103. DOI: 10.1002/ijc.30487. View

Belson M, Kingsley B, Holmes A . Risk factors for acute leukemia in children: a review. Environ Health Perspect. 2007; 115(1):138-45. PMC: 1817663. DOI: 10.1289/ehp.9023. View

Li J, Thompson T, Miller J, Pollack L, Stewart S . Cancer incidence among children and adolescents in the United States, 2001-2003. Pediatrics. 2008; 121(6):e1470-7. DOI: 10.1542/peds.2007-2964. View

Steliarova-Foucher E, Colombet M, Ries L, Moreno F, Dolya A, Bray F . International incidence of childhood cancer, 2001-10: a population-based registry study. Lancet Oncol. 2017; 18(6):719-731. PMC: 5461370. DOI: 10.1016/S1470-2045(17)30186-9. View

Valdez J, Nichols K, Kesserwan C . Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition. Br J Haematol. 2016; 176(4):539-552. DOI: 10.1111/bjh.14461. View

Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P . International Classification of Childhood Cancer, third edition. Cancer. 2005; 103(7):1457-67. DOI: 10.1002/cncr.20910. View

Bilaniuk L, Zimmerman R, Littman P, Gallo E, RORKE L, Bruce D . Computed tomography of brain stem gliomas in children. Radiology. 1980; 134(1):89-95. DOI: 10.1148/radiology.134.1.7350640. View

Raaschou-Nielsen O, Sorensen M, Carstensen H, Jensen T, Bernhardtsen T, Gjerris F . Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980-1996. Br J Cancer. 2006; 95(3):416-22. PMC: 2360646. DOI: 10.1038/sj.bjc.6603278. View

Siegel D, Li J, Henley S, Wilson R, Lunsford N, Tai E . Geographic Variation in Pediatric Cancer Incidence - United States, 2003-2014. MMWR Morb Mortal Wkly Rep. 2018; 67(25):707-713. PMC: 6023185. DOI: 10.15585/mmwr.mm6725a2. View

10.

Neale R, Stiller C, Bunch K, Milne E, Mineau G, Murphy M . Familial aggregation of childhood and adult cancer in the Utah genealogy. Int J Cancer. 2013; 133(12):2953-60. DOI: 10.1002/ijc.28300. View

11.

Papathoma P, Thomopoulos T, Karalexi M, Ryzhov A, Zborovskaya A, Dimitrova N . Childhood central nervous system tumours: Incidence and time trends in 13 Southern and Eastern European cancer registries. Eur J Cancer. 2015; 51(11):1444-55. DOI: 10.1016/j.ejca.2015.04.014. View

12.

Udaka Y, Packer R . Pediatric Brain Tumors. Neurol Clin. 2018; 36(3):533-556. DOI: 10.1016/j.ncl.2018.04.009. View

13.

Harvei S, Tretli S, Langmark F . Quality of prostate cancer data in the cancer registry of Norway. Eur J Cancer. 1996; 32A(1):104-10. DOI: 10.1016/0959-8049(95)00501-3. View

14.

Giacomazzi C, Giacomazzi J, Netto C, Santos-Silva P, Selistre S, Maia A . Pediatric cancer and Li-Fraumeni/Li-Fraumeni-like syndromes: a review for the pediatrician. Rev Assoc Med Bras (1992). 2015; 61(3):282-9. DOI: 10.1590/1806-9282.61.03.282. View

15.

Borretzen I, Lysdahl K, Olerud H . Diagnostic radiology in Norway trends in examination frequency and collective effective dose. Radiat Prot Dosimetry. 2007; 124(4):339-47. DOI: 10.1093/rpd/ncm204. View

16.

Matthews T, Hamilton B . Total Fertility Rates by State and Race and Hispanic Origin: United States, 2017. Natl Vital Stat Rep. 2019; 68(1):1-11. View

17.

Jorde L . Inbreeding in the Utah Mormons: an evaluation of estimates based on pedigrees, isonymy, and migration matrices. Ann Hum Genet. 1989; 53(4):339-55. DOI: 10.1111/j.1469-1809.1989.tb01803.x. View

18.

Shah A, Coleman M . Increasing incidence of childhood leukaemia: a controversy re-examined. Br J Cancer. 2007; 97(7):1009-12. PMC: 2360402. DOI: 10.1038/sj.bjc.6603946. View

19.

Mork J, Thoresen S, Langmark F, Glattre E . Head and neck cancer in Norway. A study of the quality of the Cancer Registry of Norway's data on head and neck cancer for the period 1953-1991. APMIS. 1995; 103(5):375-82. View

20.

Zhang J, Walsh M, Wu G, Edmonson M, Gruber T, Easton J . Germline Mutations in Predisposition Genes in Pediatric Cancer. N Engl J Med. 2015; 373(24):2336-2346. PMC: 4734119. DOI: 10.1056/NEJMoa1508054. View