Cognitive Function in Liver Transplantation

Overview

Journal Curr Transplant Rep

Date 2020 May 22

PMID 32435574

Citations 5

Authors

Somaya A M Albhaisi

Jasmohan S Bajaj

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Liver transplantation (LT) remains the only way to cure patients with severe liver diseases. Important questions about neurological sequelae and quality of life after LT have emerged. In this review, we discuss the neurocognitive changes associated with LT and we conclude with recommendations in this regard for patients, caregivers, and physicians.

Recent Findings: Compared with other solid organ recipients, LT patients tend to have a higher incidence (up to 30%) of neurological complications post-LT. Even in absence of previous episodes of hepatic encephalopathy (HE), some patients display new onset of neurological symptoms post-LT, raising the concern about the role of other factors that may have a direct impact on cognitive function.

Summary: Different mechanisms have been postulated to explain these postoperative neurological symptoms. They include sequelae of HE, persistent impairment of cognitive function due to cirrhosis, or postoperative decompensation of an unknown or undiagnosed neurodegenerative disorder.

Citing Articles

Evaluation of dynamic cerebrovascular autoregulation during liver transplantation.

Wolpert B, Rothgerber D, Rosner A, Brunier M, Kuchen R, Schramm P PLoS One. 2024; 19(7):e0305658.

PMID: 39058695 PMC: 11280153. DOI: 10.1371/journal.pone.0305658.

Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation.

Patel S, Tareen K, Patel C, Rosinski A Curr Psychiatry Rep. 2024; 26(8):436-446.

PMID: 38941032 DOI: 10.1007/s11920-024-01517-0.

Perioperative Considerations in Older Kidney and Liver Transplant Recipients: A Review.

Chanan E, Wagener G, Whitlock E, Berger J, McAdams-DeMarco M, Yeh J Transplantation. 2024; 108(11):e346-e356.

PMID: 38557579 PMC: 11442682. DOI: 10.1097/TP.0000000000005000.

Prevalence of cognitive impairment in liver transplant recipients.

Berry K, Ruck J, Barry F, Shui A, Cortella A, Kent D Clin Transplant. 2023; 38(1):e15229.

PMID: 38113284 PMC: 10842727. DOI: 10.1111/ctr.15229.

Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease.

LEcuyer S, Charbonney E, Carrier F, Rose C Neurochem Res. 2023; 49(6):1437-1449.

PMID: 36635437 DOI: 10.1007/s11064-022-03854-z.

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