Phthalate Exposure and Long-Term Epigenomic Consequences: A Review

Overview

Journal Front Genet

Date 2020 May 22

PMID 32435260

Citations 43

Authors

Sudipta Dutta

Diana K Haggerty

Daniel A Rappolee

Douglas M Ruden

Affiliations

Soon will be listed here.

Abstract

Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability and plasticity. Phthalates are not present in plastics by covalent bonds and thus can easily leach into the environment and enter the human body by dermal absorption, ingestion, or inhalation. Several and studies suggest that phthalates can act as endocrine disruptors and cause moderate reproductive and developmental toxicities. Furthermore, phthalates can pass through the placental barrier and affect the developing fetus. Thus, phthalates have ubiquitous presence in food and environment with potential adverse health effects in humans. This review focusses on studies conducted in the field of toxicogenomics of phthalates and discusses possible transgenerational and multigenerational effects caused by phthalate exposure during any point of the life-cycle.

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