Iron Bioavailability and Cardiopulmonary Function During Ascent to Very High Altitude

Overview

Journal Eur Respir J

Specialty Pulmonary Medicine

Date 2020 May 21

PMID 32430412

Citations 8

Authors

David A Holdsworth

Matthew C Frise

Josh Bakker-Dyos

Christopher Boos

Keith L Dorrington

David Woods

Adrian Mellor

Peter A Robbins

Affiliations

Soon will be listed here.

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References

Ponikowski P, Van Veldhuisen D, Comin-Colet J, Ertl G, Komajda M, Mareev V . Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency†. Eur Heart J. 2014; 36(11):657-68. PMC: 4359359. DOI: 10.1093/eurheartj/ehu385. View

Cheng X, Prange-Barczynska M, Fielding J, Zhang M, Burrell A, Lima J . Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control. J Clin Invest. 2020; 130(5):2237-2251. PMC: 7190921. DOI: 10.1172/JCI133194. View

Marshall B, Marshall C . A model for hypoxic constriction of the pulmonary circulation. J Appl Physiol (1985). 1988; 64(1):68-77. DOI: 10.1152/jappl.1988.64.1.68. View

Naeije R . Pulmonary hypertension at high altitude. Eur Respir J. 2019; 53(6). DOI: 10.1183/13993003.00985-2019. View

Alexander J, GROVER R . Mechanism of reduced cardiac stroke volume at high altitude. Clin Cardiol. 1983; 6(6):301-3. DOI: 10.1002/clc.4960060612. View

GROVES B, Reeves J, Sutton J, Wagner P, Cymerman A, Malconian M . Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol (1985). 1987; 63(2):521-30. DOI: 10.1152/jappl.1987.63.2.521. View

Bartsch P, Gibbs J . Effect of altitude on the heart and the lungs. Circulation. 2007; 116(19):2191-202. DOI: 10.1161/CIRCULATIONAHA.106.650796. View

Abbas A, Fortuin F, Schiller N, Appleton C, Moreno C, Lester S . A simple method for noninvasive estimation of pulmonary vascular resistance. J Am Coll Cardiol. 2003; 41(6):1021-7. DOI: 10.1016/s0735-1097(02)02973-x. View

Smith T, Talbot N, Privat C, Rivera-Ch M, Nickol A, Ratcliffe P . Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA. 2009; 302(13):1444-50. DOI: 10.1001/jama.2009.1404. View

10.

Maufrais C, Rupp T, Bouzat P, Doucende G, Verges S, Nottin S . Heart mechanics at high altitude: 6 days on the top of Europe. Eur Heart J Cardiovasc Imaging. 2017; 18(12):1369-1377. DOI: 10.1093/ehjci/jew286. View

11.

Talbot N, Smith T, Lakhal-Littleton S, Gulsever C, Rivera-Ch M, Dorrington K . Suppression of plasma hepcidin by venesection during steady-state hypoxia. Blood. 2016; 127(9):1206-7. DOI: 10.1182/blood-2015-05-647404. View

12.

Ren X, Dorrington K, Maxwell P, Robbins P . Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. J Appl Physiol (1985). 2000; 89(2):680-6. DOI: 10.1152/jappl.2000.89.2.680. View

13.

Skikne B, Punnonen K, Caldron P, Bennett M, Rehu M, Gasior G . Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. Am J Hematol. 2011; 86(11):923-7. DOI: 10.1002/ajh.22108. View

14.

Frise M, Cheng H, Nickol A, Curtis M, Pollard K, Roberts D . Clinical iron deficiency disturbs normal human responses to hypoxia. J Clin Invest. 2016; 126(6):2139-50. PMC: 4887172. DOI: 10.1172/JCI85715. View