Urinary Metabolomic Profiling Analysis and Evaluation of the Effect of Extract Intake

Overview

Journal Nutrients

Date 2020 May 20

PMID 32422870

Citations 3

Authors

Juyeon Kim

Youngae Jung

Eunok Lee

Seoyeong Jang

Do Hyun Ryu

Oran Kwon

Geum-Sook Hwang

Affiliations

Soon will be listed here.

Abstract

Metabolomics is a powerful tool for the investigation of interactions between diet, nutrients, and human metabolism. is an edible brown alga that is abundantly found in Korea and Japan and contains unique polyphenols referred to as phlorotannins. However, there are few metabolomics studies related to the effects of polyphenols in humans. In this study, we performed a mass spectrometry-based metabolomics analysis of urine samples from participants with a body mass index (BMI) higher than 25 kg/m and lower than 30 kg/m to investigate the effects of the intake of seapolynol isolated from . Metabolomic profiling showed that the levels of riboflavin, urocanic acid, 5-hydroxy-6-methoxyindole glucuronide, and guanidino valeric acid were significantly increased in the seapolynol intake group compared with the placebo group. A correlation analysis was performed to identify the association between the metabolites' levels and clinical characteristics related to body fat. Among the metabolites whose concentrations changed in the seapolynol intake group, riboflavin was associated with BMI, body weight, fat mass, and percent body fat. These findings suggest that the decreased body fat induced by the intake of seapolynol is related to an increase in the antioxidant effect of riboflavin.

Citing Articles

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