Implications of SARSr-CoV 2 Infection in Thalassemias: Do Patients Fall into the "high Clinical Risk" Category?

Overview

Journal Acta Biomed

Specialty General Medicine

Date 2020 May 19

PMID 32420925

Citations 13

Authors

Mehran Karimi

Vincenzo De Sanctis

Affiliations

Soon will be listed here.

Abstract

We're all flying blind regarding coronavirus, but it's fair to think if thalassemic patients are particularly vulnerable to SARS-COV-2 infection or are at potential higher risk of complications from COVID-19 than normal population, specially when they become older. The frustrating thing is that, right now, this virus is still new. It only came to the attention of the World Health Organization at the end of December. Very few cases in thalassemia have so far been reported; is this due to lack of testing or a true lack of infection/susceptibility? However, we believe that more data should be collected to better characterise the impact of SARS-CoV-2 infection in patients with thalassemias. Therefore, a multicenter registry and the collection of comprehensive data from both positive COVID-19 thalassemia major and non-transfusion dependent thalassemia are necessary to clarify debated issues. In the meantime an early and vigilant monitoring along with high quality supportive care are needed in thalassemic patients at high risk for SARS-CoV-2 infection.

Citing Articles

Expert Consensus: Main Risk Factors for Poor Prognosis in COVID-19 and the Implications for Targeted Measures against SARS-CoV-2.

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COVID-19 and β-thalassemia: in lieu of evidence and vague nexus.

Al-Kuraishy H, Ashour M, Saad H, El-Saber Batiha G Ann Hematol. 2023; 103(5):1423-1433.

PMID: 37405444 DOI: 10.1007/s00277-023-05346-8.

COVID-19 pandemic and care of transfusion-dependent patients of thalassaemia: Experience from a paediatric centre in North India.

Parakh N, Pahuja S, Singh V, Kumar N, Chandra J J Paediatr Child Health. 2022; 58(10):1760-1765.

PMID: 35789061 PMC: 9350329. DOI: 10.1111/jpc.16082.

Efficacy and Safety of Sinopharm Vaccine for SARS-CoV-2 and breakthrough infections in Iranian Patients with Hemoglobinopathies: A Preliminary Report.

Karimi M, Zarei T, Haghpanah S, Azarkeivan A, Naderi M, Matin S Mediterr J Hematol Infect Dis. 2022; 14(1):e2022026.

PMID: 35444764 PMC: 8992638. DOI: 10.4084/MJHID.2022.026.

COVID-19 in Patients with Transfusion Dependent Thalassemia (TDT) in Indonesia: Characteristics of the Disease and Patients, and Comparison between Epidemiological Data for COVID-19 and Thalassemia in Indonesia and Southeast Asia.

Atmakusuma T Hematol Rep. 2022; 14(1):2-12.

PMID: 35323173 PMC: 8953260. DOI: 10.3390/hematolrep14010002.

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