Characteristics of Novel Ti-10Mo-xCu Alloy by Powder Metallurgy for Potential Biomedical Implant Applications

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2020 May 19

PMID 32420516

Citations 6

Authors

Wei Xu

Chenjin Hou

Yuxuan Mao

Lei Yang

Maryam Tamaddon

Jianliang Zhang

Xuanhui Qu

Chaozong Liu

Bo Su

Xin Lu

Affiliations

Soon will be listed here.

Abstract

When biomaterials are implanted in the human body, the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation, causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery. Ti-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement, and the prevention of infection of Ti-Mo implants is therefore crucial. In this study, bacterial inhibitory copper (Cu) was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory property. The effects of Cu content on microstructure, tensile properties, cytocompatibility, and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically investigated. Results revealed that Ti-10Mo-1Cu alloy consisted of α and β phases, while there were a few TiCu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys, in addition to α and β phases. The tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation decreased. Ti-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%. Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation. Bacterial inhibitory rates against and increased with the increase in Cu content of Ti-10Mo-xCu alloy, within the ranges of 20-60% and 15-50%, respectively. Taken together, this study suggests that Ti-10Mo-3Cu alloy with high strength, acceptable elongation, excellent cytocompatibility, and the bacterial inhibitory property is a promising candidate for biomedical implant applications.

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