Prevalence of Hyperhomocysteinaemia and Associated Factors Among Ethiopian Adult Population in a 2015 National Survey

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2020 May 19

PMID 32420383

Citations 8

Authors

Feyissa Challa

Tigist Getahun

Meron Sileshi

Bikila Nigassie

Zeleke Geto

Genet Ashibire

Terefe Gelibo

Solomon Teferra

Daniel Seifu

Yohannes Sitotaw

Abebe Bekele

Ebba Abate

Kaleab Baye

Affiliations

Soon will be listed here.

Abstract

Hyperhomocysteinaemia (HHcy) is an independent risk factor for major cardiovascular diseases, but data on the prevalence and predictors of HHcy in low- and middle-income countries like Ethiopia are scant. The aim of this study was to estimate the prevalence of HHcy and associated risk factors in the Ethiopian adult population. A cross-sectional survey on risks of noncommunicable diseases (NCDs) using the STEPwise approach to surveillance (STEPS) survey was conducted between April and June 2015. A total of 4,175 study participants were surveyed. Serum homocysteine (Hcy) and metabolic profile were determined using Cobas Integra 400 Plus and CardioChek PA analyzer, respectively. Factors associated with HHcy were determined using logistic regression. The mean serum tHcy concentration was 14.6 mol/L, with 16.4 mol/L in males and 13.4 mol/L in females. Overall, 38% had HHcy, with figures in males (49%) higher than females (30%). Increased age, being male, and high blood pressure and/or taking blood pressure medication, as well as low consumption of fruit and/or vegetables, were independent risk factors for HHcy. In conclusion, the prevalence of HHcy among the adult Ethiopian population is alarmingly high. Improving diets through the promotion of fruit and vegetable consumption is needed to reduce the risk of NCDs.

Citing Articles

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