Alcohol and Multiple Sclerosis: an Immune System-based Review

Overview

Journal Int J Physiol Pathophysiol Pharmacol

Date 2020 May 19

PMID 32419901

Citations 27

Authors

Maryam Fahim

Aryan Rafiee Zadeh

Pouria Shoureshi

Keyvan Ghadimi

Masoumeh Cheshmavar

Neda Sheikhinia

Mahdieh Afzali

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). Although the exact etiology of multiple sclerosis is unknown, researchers suggest that genetic, environmental, and microbial factors play a central role in causing multiple sclerosis. Pathology of multiple sclerosis is based on inflammation as T cells enter the brain via disruptions in the blood-brain barrier, recognizing myelin as foreign antigen; and as a result, the T cells attack myelin and start the inflammatory processes, enhancing inflammatory cytokines and antibodies. Since previous studies show ethanol can suppress the immune system such as innate, humoral, and cellular immunity and increases the production of anti-inflammatory cytokines, we hypothesized maybe ethanol also have ameliorating effects on multiple sclerosis symptoms. Although alcohol induces apoptosis in oligodendrocytes and neurons, causing demyelination and affects CNS directly, in this study we will investigate ethanol's effects on some aspects of the immune system in multiple sclerosis.

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