Experiences of Discrimination and Urinary Catecholamine Concentrations: Longitudinal Associations in a College Student Sample

Overview

Journal Ann Behav Med

Publisher Oxford University Press

Specialty Social Sciences

Date 2020 May 17

PMID 32415831

Citations 7

Authors

Lydia K Homandberg

Thomas E Fuller-Rowell

Affiliations

Soon will be listed here.

Abstract

Background: Experiences of discrimination are a risk factor for subsequent cardiovascular disease. However, there is a lack of longitudinal research examining associations between discrimination and urinary catecholamines. This is surprising given the likely mediating role of sympathetic nervous system dysregulation in the association between psychosocial stress and cardiovascular morbidity.

Purpose: The current study examined the 3 year longitudinal association between experiences of discrimination and urinary catecholamines.

Methods: The sample included 149 college students (mean age at baseline = 18.8, standard deviation = 0.96; 45% Black/African American; 55% White/European American). Concentrations of epinephrine and norepinephrine-urinary catecholamines with established links to psychosocial stress exposure and subsequent morbidity-were determined from 12 hr overnight samples.

Results: Results indicated that experiences of discrimination were associated with increases in both epinephrine (β = .284, standard error [SE] = .117, p = .015) and norepinephrine (β = .306, SE = .114, p = .001). These longitudinal associations persisted after adjusting for negative affect, depression, and rejection sensitivity and did not vary as a function of race/ethnicity.

Conclusions: Results suggest that examination of overnight urinary catecholamines as a biological mediator of associations between experiences of discrimination and cardiovascular morbidity is warranted.

Citing Articles

Mental stress objective screening for workers using urinary neurotransmitters.

Tanabe K, Yokota A PLoS One. 2023; 18(9):e0287613.

PMID: 37682855 PMC: 10490881. DOI: 10.1371/journal.pone.0287613.

Belonging Exacerbates the Relations Between Racial Climate Stress and Physiological Dysregulation.

Doan S, Davis A, Lazarus M, Poudel A, Tran P, Clark N J Racial Ethn Health Disparities. 2023; 11(5):2786-2795.

PMID: 37676634 PMC: 11480110. DOI: 10.1007/s40615-023-01740-0.

Unlocking Population-Specific Treatments to Render Equitable Approaches and Management in Cardiovascular Disease: Development of a Situation-Specific Theory for African American Emerging Adults.

Smith S, Abshire D, Magwood G, Herbert L, Tavakoli A, Jenerette C J Cardiovasc Nurs. 2023; 39(4):E103-E114.

PMID: 37052582 PMC: 10564967. DOI: 10.1097/JCN.0000000000000986.

By what molecular mechanisms do social determinants impact cardiometabolic risk?.

Baumer Y, Pita M, Baez A, Ortiz-Whittingham L, Cintron M, Rose R Clin Sci (Lond). 2023; 137(6):469-494.

PMID: 36960908 PMC: 10039705. DOI: 10.1042/CS20220304.

Relationship between Urinary Metabolomic Profiles and Depressive Episode in Antarctica.

Kasuya K, Imura S, Ishikawa T, Sugimoto M, Inoue T Int J Mol Sci. 2023; 24(2).

PMID: 36674456 PMC: 9861393. DOI: 10.3390/ijms24020943.

References

Fuller-Rowell T, Curtis D, El-Sheikh M, Duke A, Ryff C, Zgierska A . Racial discrimination mediates race differences in sleep problems: A longitudinal analysis. Cultur Divers Ethnic Minor Psychol. 2016; 23(2):165-173. PMC: 5243865. DOI: 10.1037/cdp0000104. View

Bundy J, Li C, Stuchlik P, Bu X, Kelly T, Mills K . Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis. JAMA Cardiol. 2017; 2(7):775-781. PMC: 5710614. DOI: 10.1001/jamacardio.2017.1421. View

Masi C, Rickett E, Hawkley L, Cacioppo J . Gender and ethnic differences in urinary stress hormones: the population-based Chicago Health, Aging, and Social Relations Study. J Appl Physiol (1985). 2004; 97(3):941-7. DOI: 10.1152/japplphysiol.00256.2004. View

Fuller-Rowell T, Evans G, Ong A . Poverty and health: the mediating role of perceived discrimination. Psychol Sci. 2012; 23(7):734-9. DOI: 10.1177/0956797612439720. View

Mayrl D, Saperstein A . When white people report racial discrimination: The role of region, religion, and politics. Soc Sci Res. 2013; 42(3):742-54. DOI: 10.1016/j.ssresearch.2012.12.007. View

Castro-Diehl C, Diez Roux A, Seeman T, Shea S, Shrager S, Tadros S . Associations of socioeconomic and psychosocial factors with urinary measures of cortisol and catecholamines in the Multi-Ethnic Study of Atherosclerosis (MESA). Psychoneuroendocrinology. 2014; 41:132-41. PMC: 3985093. DOI: 10.1016/j.psyneuen.2013.12.013. View

Lewis T, Williams D, Tamene M, Clark C . Self-Reported Experiences of Discrimination and Cardiovascular Disease. Curr Cardiovasc Risk Rep. 2014; 8(1):365. PMC: 3980947. DOI: 10.1007/s12170-013-0365-2. View

Conti G, Heckman J, Urzua S . THE EDUCATION-HEALTH GRADIENT. Am Econ Rev. 2014; 100(2):234-238. PMC: 3985402. DOI: 10.1257/aer.100.2.234. View

Curtis D, Fuller-Rowell T, Doan S, Zgierska A, Ryff C . Racial and socioeconomic disparities in body mass index among college students: understanding the role of early life adversity. J Behav Med. 2016; 39(5):866-75. PMC: 6964025. DOI: 10.1007/s10865-016-9756-4. View

10.

Naimi T, Brewer R, Mokdad A, Denny C, Serdula M, Marks J . Binge drinking among US adults. JAMA. 2002; 289(1):70-5. DOI: 10.1001/jama.289.1.70. View

11.

Hilmert C, Dominguez T, Dunkel Schetter C, Srinivas S, Glynn L, Hobel C . Lifetime racism and blood pressure changes during pregnancy: implications for fetal growth. Health Psychol. 2013; 33(1):43-51. PMC: 9590305. DOI: 10.1037/a0031160. View

12.

Paine N, Watkins L, Blumenthal J, Kuhn C, Sherwood A . Association of depressive and anxiety symptoms with 24-hour urinary catecholamines in individuals with untreated high blood pressure. Psychosom Med. 2015; 77(2):136-44. PMC: 5119914. DOI: 10.1097/PSY.0000000000000144. View

13.

Ettehad D, Emdin C, Kiran A, Anderson S, Callender T, Emberson J . Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016; 387(10022):957-967. DOI: 10.1016/S0140-6736(15)01225-8. View

14.

Wei M, Ku T, Liao K . Minority stress and college persistence attitudes among African American, Asian American, and Latino students: perception of university environment as a mediator. Cultur Divers Ethnic Minor Psychol. 2011; 17(2):195-203. DOI: 10.1037/a0023359. View

15.

Friedman E, Williams D, Singer B, Ryff C . Chronic discrimination predicts higher circulating levels of E-selectin in a national sample: the MIDUS study. Brain Behav Immun. 2009; 23(5):684-92. PMC: 2745951. DOI: 10.1016/j.bbi.2009.01.002. View

16.

Krieger N, Sidney S . Racial discrimination and blood pressure: the CARDIA Study of young black and white adults. Am J Public Health. 1996; 86(10):1370-8. PMC: 1380646. DOI: 10.2105/ajph.86.10.1370. View

17.

Park C, Clark E, Schulz E, Williams B, Williams R, Holt C . Unique contribution of education to behavioral and psychosocial antecedents of health in a national sample of African Americans. J Behav Med. 2019; 42(5):860-872. PMC: 6610845. DOI: 10.1007/s10865-018-00009-w. View

18.

Brodish A, Cogburn C, Fuller-Rowell T, Peck S, Malanchuk O, Eccles J . Perceived Racial Discrimination as a Predictor of Health Behaviors: the Moderating Role of Gender. Race Soc Probl. 2012; 3(3):160-169. PMC: 3403827. DOI: 10.1007/s12552-011-9050-6. View

19.

Goosby B, Malone S, Richardson E, Cheadle J, Williams D . Perceived discrimination and markers of cardiovascular risk among low-income African American youth. Am J Hum Biol. 2015; 27(4):546-52. PMC: 4478198. DOI: 10.1002/ajhb.22683. View

20.

Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck M . Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003; 42(4):474-80. DOI: 10.1161/01.HYP.0000091371.53502.D3. View