Epigenomics and Transcriptomics Analyses of Multiple System Atrophy Brain Tissue Supports a Role for Inflammatory Processes in Disease Pathogenesis

Overview

Journal Acta Neuropathol Commun

Publisher Biomed Central

Specialty Neurology

Date 2020 May 16

PMID 32410669

Citations 5

Authors

Conceicao Bettencourt

Ignazio S Piras

Sandrine C Foti

Joshua Talboom

Yasuo Miki

Tammaryn Lashley

Robert Balazs

Emmanuelle Vire

Thomas T Warner

Matt J Huentelman

Janice L Holton

Affiliations

Soon will be listed here.

Citing Articles

DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson's disease, and progressive supranuclear palsy: a cross-comparative investigation.

Murthy M, Fodder K, Miki Y, Rambarack N, De Pablo Fernandez E, Pihlstrom L Acta Neuropathol. 2024; 148(1):4.

PMID: 38995454 PMC: 11245434. DOI: 10.1007/s00401-024-02764-4.

Inflammation in multiple system atrophy.

Lenska-Mieciek M, Madetko-Alster N, Alster P, Krolicki L, Fiszer U, Koziorowski D Front Immunol. 2023; 14:1214677.

PMID: 37426656 PMC: 10327640. DOI: 10.3389/fimmu.2023.1214677.

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

Hopfner F, Tietz A, Ruf V, Ross O, Koga S, Dickson D Mov Disord. 2022; 37(10):2110-2121.

PMID: 35997131 PMC: 10052809. DOI: 10.1002/mds.29164.

Neurodegenerative movement disorders: An epigenetics perspective and promise for the future.

Murthy M, Cheng Y, Holton J, Bettencourt C Neuropathol Appl Neurobiol. 2021; 47(7):897-909.

PMID: 34318515 PMC: 9291277. DOI: 10.1111/nan.12757.

MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.

Bettencourt C, Miki Y, Piras I, de Silva R, Foti S, Talboom J Neuropathol Appl Neurobiol. 2020; 47(5):640-652.

PMID: 33368549 PMC: 8219819. DOI: 10.1111/nan.12688.

References

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Bettencourt C, Foti S, Miki Y, Botia J, Chatterjee A, Warner T . White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy. Acta Neuropathol. 2019; 139(1):135-156. PMC: 6942018. DOI: 10.1007/s00401-019-02074-0. View

Piras I, Bleul C, Schrauwen I, Talboom J, Llaci L, De Both M . Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease. Acta Neuropathol Commun. 2020; 8(1):76. PMC: 7268362. DOI: 10.1186/s40478-020-00950-5. View

Spillantini M, Crowther R, Jakes R, Cairns N, Lantos P, Goedert M . Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett. 1998; 251(3):205-8. DOI: 10.1016/s0304-3940(98)00504-7. View