Can Changes in Implant Macrogeometry Accelerate the Osseointegration Process?: An in Vivo Experimental Biomechanical and Histological Evaluations

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 May 15

PMID 32407416

Citations 8

Authors

Sergio Alexandre Gehrke

Jaime Aramburu Junior

Leticia Perez-Diaz

Tales Dias do Prado

Berenice Anina Dedavid

Patricia Mazon

Piedad N De Aza

Affiliations

Soon will be listed here.

Abstract

Objectives: The propose was to compare this new implant macrogeometry with a control implant with a conventional macrogeometry.

Materials And Methods: Eighty-six conical implants were divided in two groups (n = 43 per group): group control (group CON) that were used conical implants with a conventional macrogeometry and, group test (group TEST) that were used implants with the new macrogeometry. The new implant macrogeometry show several circular healing cambers between the threads, distributed in the implant body. Three implants of each group were used to scanning electronic microscopy (SEM) analysis and, other eighty samples (n = 40 per group) were inserted the tibia of ten rabbit (n = 2 per tibia), determined by randomization. The animals were sacrificed (n = 5 per time) at 3-weeks (Time 1) and at 4-weeks after the implantations (Time 2). The biomechanical evaluation proposed was the measurement of the implant stability quotient (ISQ) and the removal torque values (RTv). The microscopical analysis was a histomorphometric measurement of the bone to implant contact (%BIC) and the SEM evaluation of the bone adhered on the removed implants.

Results: The results showed that the implants of the group TEST produced a significant enhancement in the osseointegration in comparison with the group CON. The ISQ and RTv tests showed superior values for the group TEST in the both measured times (3- and 4-weeks), with significant differences (p < 0.05). More residual bone in quantity and quality was observed in the samples of the group TEST on the surface of the removed implants. Moreover, the %BIC demonstrated an important increasing for the group TEST in both times, with statistical differences (in Time 1 p = 0.0103 and in Time 2 p < 0.0003).

Conclusions: Then, we can conclude that the alterations in the implant macrogeometry promote several benefits on the osseointegration process.

Citing Articles

Comparison Between Micro- and Micro-Nano Surface Texturization in the Initial Osseointegration Process: An Experimental In Vitro and In Vivo Preclinical Study.

Gehrke S, da Costa E, Junior J, Eilers Treichel T, Fabbro M, Scarano A Bioengineering (Basel). 2025; 12(2).

PMID: 40001694 PMC: 11851884. DOI: 10.3390/bioengineering12020175.

Analysis of osseointegration of implants with macrogeometries with healing chambers: a randomized clinical trial.

da Rosa de Souza P, Manfro R, de Salles Santos F, Garcia G, Macedo N, de Macedo B BMC Oral Health. 2024; 24(1):1114.

PMID: 39300380 PMC: 11412014. DOI: 10.1186/s12903-024-04857-8.

Primary stability evaluation of different morse cone implants in low-density artificial bone blocks: A comparison between high-and low-speed drilling.

Romasco T, De Bortoli Jr N, Paulo De Bortoli J, Jayme S, Piattelli A, Di Pietro N Heliyon. 2024; 10(15):e35225.

PMID: 39170202 PMC: 11336439. DOI: 10.1016/j.heliyon.2024.e35225.

Micro-Computed Tomography Analysis of Peri-Implant Bone Defects Exposed to a Peri-Implantitis Microcosm, with and without Bone Substitute, in a Rabbit Model: A Pilot Study.

Panes C, Valdivia-Gandur I, Veuthey C, Sousa V, Del Sol M, Beltran V Bioengineering (Basel). 2024; 11(4).

PMID: 38671818 PMC: 11048142. DOI: 10.3390/bioengineering11040397.

Randomized Clinical Trial Comparing Insertion Torque and Implant Stability of Two Different Implant Macrogeometries in the Initial Periods of Osseointegration.

Gehrke S, Cortellari G, Fernandes G, Scarano A, Martins R, Moreira Cancado R Medicina (Kaunas). 2023; 59(1).

PMID: 36676792 PMC: 9862599. DOI: 10.3390/medicina59010168.

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