Role of Interleukin-15 in Cardiovascular Diseases

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2020 May 15

PMID 32406586

Citations 24

Authors

Lei Guo

Ming-Fei Liu

Ji-Niu Huang

Jia-Min Li

Jun Jiang

Jian-An Wang

Affiliations

Soon will be listed here.

Abstract

Interleukin (IL)-15 is a recently identified cytokine, which belongs to the interleukin-2(IL-2) family, and plays an important role in innate and adaptive immunoreaction. Given the fact that the structure of IL-15 is partially similar to IL-2, they share some common biological effects, including immunoregulation. IL-2 was proven to protect cardiac function in mouse myocardial infarction models. Cardiovascular diseases (CVDs) dominate the cause of mortality worldwide. Besides atherosclerosis, inflammation is also widely involved in the pathogenesis of many CVDs including hypertension, heart failure (HF) and aneurysm. IL-15, as a pro-inflammatory cytokine, is up-regulated in some cardiovascular diseases, such as myocardial infarction and atherosclerosis. The current understanding of IL-15, including its signal pathway and cellular function, was described. Furthermore, IL-15 has a protective effect in myocardial infarction and myocarditis by decreasing cardiomyocyte death and improving heart function. The inhibited effect of IL-15 in ductus arteriosus (DA) should be focused on. IL-15 promoted atherogenesis. IL-15 may be a good target in treatment of cardiovascular diabetology. Finally, future research direction of IL-15 deserves attention. Since IL-15 plays several roles in CVDs, understanding the role of the IL-15/IL-15R system may provide a scientific basis for the development of new approaches that use IL-15 for the treatment of CVDs.

Citing Articles

Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in Mice.

Longtine A, Greenberg N, Gonzalez A, Lindquist A, VanDongen N, Mahoney S Aging Biol. 2025; 2.

PMID: 39897133 PMC: 11785404. DOI: 10.59368/agingbio.20240033.

Identification of novel proteins for coronary artery disease by integrating GWAS data and human plasma proteomes.

Li J, Wei J, Fu P, Gu J Heliyon. 2024; 10(19):e38036.

PMID: 39386869 PMC: 11462259. DOI: 10.1016/j.heliyon.2024.e38036.

Advancing microbiome research in Māori populations: insights from recent literature exploring the gut microbiomes of underrepresented and Indigenous peoples.

Silk E, Bayer S, Foster M, Roy N, Taylor M, Vatanen T mSystems. 2024; 9(11):e0090924.

PMID: 39365053 PMC: 11575238. DOI: 10.1128/msystems.00909-24.

Postmortem Immunohistochemical Findings in Early Acute Myocardial Infarction: A Systematic Review.

Isaila O, Ion O, Luta R, Catinas R, Ionita A, Haisan D Int J Mol Sci. 2024; 25(14).

PMID: 39062865 PMC: 11277133. DOI: 10.3390/ijms25147625.

Coronavirus disease 2019-related myocarditis genes contribute to ECMO prognosis.

Yan A, Zhang R, Feng C, Feng J BMC Cardiovasc Disord. 2024; 24(1):375.

PMID: 39026189 PMC: 11264513. DOI: 10.1186/s12872-024-04032-5.

References

Duan Y, Li F, Wang W, Guo Q, Wen C, Li Y . Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives. Obes Rev. 2017; 18(10):1147-1158. DOI: 10.1111/obr.12567. View

Turillazzi E, DI Paolo M, Neri M, Riezzo I, Fineschi V . A theoretical timeline for myocardial infarction: immunohistochemical evaluation and western blot quantification for Interleukin-15 and Monocyte chemotactic protein-1 as very early markers. J Transl Med. 2014; 12:188. PMC: 4094437. DOI: 10.1186/1479-5876-12-188. View

Meghnem D, Morisseau S, Frutoso M, Trillet K, Maillasson M, Barbieux I . Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor. J Immunol. 2017; 198(12):4563-4568. DOI: 10.4049/jimmunol.1700046. View

Yargic M, Torgutalp S, Akin S, Babayeva N, Torgutalp M, Demirel H . Acute long-distance trail running increases serum IL-6, IL-15, and Hsp72 levels. Appl Physiol Nutr Metab. 2018; 44(6):627-631. DOI: 10.1139/apnm-2018-0520. View

Quinn L, Anderson B . Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies. J Obes. 2011; 2011:456347. PMC: 3092601. DOI: 10.1155/2011/456347. View

Manohar M, Kandikattu H, Verma A, Mishra A . IL-15 regulates fibrosis and inflammation in a mouse model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2018; 315(6):G954-G965. PMC: 6336943. DOI: 10.1152/ajpgi.00139.2018. View

Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N . Cloning of the gamma chain of the human IL-2 receptor. Science. 1992; 257(5068):379-82. DOI: 10.1126/science.1631559. View

Bouchentouf M, Williams P, Forner K, Cuerquis J, Michaud V, Paradis P . Interleukin-2 enhances angiogenesis and preserves cardiac function following myocardial infarction. Cytokine. 2011; 56(3):732-8. DOI: 10.1016/j.cyto.2011.09.023. View

Slomp J, Van Munsteren J, Poelmann R, de Reeder E, Bogers A, Gittenberger-de Groot A . Formation of intimal cushions in the ductus arteriosus as a model for vascular intimal thickening. An immunohistochemical study of changes in extracellular matrix components. Atherosclerosis. 1992; 93(1-2):25-39. DOI: 10.1016/0021-9150(92)90197-o. View

10.

Park C, Yoon S, Armitage R, Choi Y . Follicular dendritic cells produce IL-15 that enhances germinal center B cell proliferation in membrane-bound form. J Immunol. 2004; 173(11):6676-83. DOI: 10.4049/jimmunol.173.11.6676. View

11.

Mattei F, Schiavoni G, Belardelli F, Tough D . IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J Immunol. 2001; 167(3):1179-87. DOI: 10.4049/jimmunol.167.3.1179. View

12.

Aoyama N, Kure K, Minabe M, Izumi Y . Increased Heart Failure Prevalence in Patients with a High Antibody Level Against Periodontal Pathogen. Int Heart J. 2019; 60(5):1142-1146. DOI: 10.1536/ihj.19-010. View

13.

Quinn L, Anderson B, Conner J, Pistilli E, Wolden-Hanson T . Overexpression of interleukin-15 in mice promotes resistance to diet-induced obesity, increased insulin sensitivity, and markers of oxidative skeletal muscle metabolism. Int J Interferon Cytokine Mediat Res. 2017; 3:29-42. PMC: 5605924. DOI: 10.2147/IJICMR.S19007. View

14.

Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Pariggiano I . Inflammation and cardiovascular disease: from pathogenesis to therapeutic target. Curr Atheroscler Rep. 2014; 16(9):435. DOI: 10.1007/s11883-014-0435-z. View

15.

Fisman E, Tenenbaum A . Cardiovascular diabetology: clinical, metabolic and inflammatory facets. Preface. Adv Cardiol. 2008; 45:xi-xiii. View

16.

Busquets S, Figueras M, Meijsing S, Carbo N, Quinn L, Almendro V . Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect. Int J Mol Med. 2005; 16(3):471-6. View

17.

Dubois S, Mariner J, Waldmann T, Tagaya Y . IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity. 2002; 17(5):537-47. DOI: 10.1016/s1074-7613(02)00429-6. View

18.

Abeywardena M, Leifert W, Warnes K, Varghese J, Head R . Cardiovascular biology of interleukin-6. Curr Pharm Des. 2009; 15(15):1809-21. DOI: 10.2174/138161209788186290. View

19.

Ferrari R, Bueno H, Chioncel O, Cleland J, Stough W, Lettino M . Acute heart failure: lessons learned, roads ahead. Eur J Heart Fail. 2018; 20(5):842-850. DOI: 10.1002/ejhf.1169. View

20.

Calais F, Eriksson Ostman M, Hedberg P, Rosenblad A, Leppert J, Frobert O . Incremental prognostic value of coronary and systemic atherosclerosis after myocardial infarction. Int J Cardiol. 2018; 261:6-11. DOI: 10.1016/j.ijcard.2018.02.035. View