Lipotransfer Provides Effective Soft Tissue Replacement for Acquired Partial Lipodystrophy

Overview

Journal BMJ Case Rep

Specialty General Medicine

Date 2020 May 15

PMID 32404319

Citations 1

Authors

Faith Hyun Kyung Jeon

Michelle Griffin

Carole Frosdick

Peter Edward Michael Butler

Affiliations

Soon will be listed here.

Abstract

We present a 48-year-old female patient who presented with features consistent with acquired partial lipodystrophy (APL) also known as 'Barraquer-Simons syndrome'. It is a rare disease characterised by a gradual and progressive onset of lipoatrophy limited to the face, neck, upper limbs, thorax and abdomen and sparing the lower extremities. The resultant physical appearance can have significant psychosocial sequelae, further compounded by misdiagnosis and delay in recognition and management. Treatment is aimed at surgical correction of soft tissue destruction. Autologous fat transfer is an established plastic and reconstructive procedure that is safe and minimally invasive and can be used to reconstruct a variety of soft tissue defects and has shown to be an effective treatment modality in patients with APL.

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References

Oliveira J, Freitas P, Lau E, Carvalho D . Barraquer-Simons syndrome: a rare form of acquired lipodystrophy. BMC Res Notes. 2016; 9:175. PMC: 4797229. DOI: 10.1186/s13104-016-1975-9. View

Hunstad J, Shifrin D, Kortesis B . Successful treatment of Parry-Romberg syndrome with autologous fat grafting: 14-year follow-up and review. Ann Plast Surg. 2011; 67(4):423-5. DOI: 10.1097/SAP.0b013e31820b3aa8. View

Coleman S . Structural fat grafting: more than a permanent filler. Plast Reconstr Surg. 2006; 118(3 Suppl):108S-120S. DOI: 10.1097/01.prs.0000234610.81672.e7. View

Coleman S . Structural fat grafts: the ideal filler?. Clin Plast Surg. 2001; 28(1):111-9. View

Denadai R, Buzzo C, Raposo-Amaral C, Raposo-Amaral C . Facial Contour Symmetry Outcomes after Site-Specific Facial Fat Compartment Augmentation with Fat Grafting in Facial Deformities. Plast Reconstr Surg. 2019; 143(2):544-556. DOI: 10.1097/PRS.0000000000005220. View

Capeau J, Magre J, Caron-Debarle M, Lagathu C, Antoine B, Bereziat V . Human lipodystrophies: genetic and acquired diseases of adipose tissue. Endocr Dev. 2010; 19:1-20. PMC: 3892722. DOI: 10.1159/000316893. View

Nolis T . Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies. J Hum Genet. 2013; 59(1):16-23. DOI: 10.1038/jhg.2013.107. View

Palmero M, Uziel Y, Laxer R, Forrest C, Pope E . En coup de sabre scleroderma and Parry-Romberg syndrome in adolescents: surgical options and patient-related outcomes. J Rheumatol. 2010; 37(10):2174-9. DOI: 10.3899/jrheum.100062. View

Serra J, Ballesteros A, Mesa F, Bazan A, Paloma V, Sanz J . Use of the temporal muscle flap in Barraquer-Simon's progressive lipodystrophy. Ann Plast Surg. 1993; 30(2):180-2. DOI: 10.1097/00000637-199302000-00016. View

10.

Guaraldi G, Murri R, Orlando G, Giovanardi C, Squillace N, Vandelli M . Severity of lipodystrophy is associated with decreased health-related quality of life. AIDS Patient Care STDS. 2008; 22(7):577-85. PMC: 2929152. DOI: 10.1089/apc.2007.0173. View

11.

Guelinckx P, Sinsel N . Facial contour restoration in Barraquer-Simons syndrome using two free anterolateral thigh flaps. Plast Reconstr Surg. 2000; 105(5):1730-6. DOI: 10.1097/00006534-200004050-00019. View

12.

Zhang A, Moraites E, Goldfarb N, Liszewski W, Farah R . Acquired partial lipodystrophy treated with poly-L-lactic acid and hyaluronic acid fillers: a case report. J Cosmet Laser Ther. 2018; 21(4):201-202. DOI: 10.1080/14764172.2018.1511909. View

13.

Hunter A, Lawson A, Thomson D . Partial lipodystrophy with nephrotic syndrome. Postgrad Med J. 1978; 54(630):286-91. PMC: 2425238. DOI: 10.1136/pgmj.54.630.286. View

14.

Heidemann L, Thomsen J, Sorensen J . Barraquer-Simons syndrome: a unique patient's perspective on diagnosis, disease progression and recontouring treatment. BMJ Case Rep. 2016; 2016. PMC: 4956967. DOI: 10.1136/bcr-2016-216134. View

15.

Corvillo F, Akinci B . An overview of lipodystrophy and the role of the complement system. Mol Immunol. 2019; 112:223-232. DOI: 10.1016/j.molimm.2019.05.011. View

16.

Vyas K, Vasconez H, Morrison S, Mogni B, Linton S, Hockensmith L . Fat Graft Enrichment Strategies: A Systematic Review. Plast Reconstr Surg. 2020; 145(3):827-841. DOI: 10.1097/PRS.0000000000006557. View

17.

Glaser D, Kenkel J, Paradkar-Mitragotri D, Murphy D, Romagnano L, Drinkwater A . Duration of effect by injection volume and facial subregion for a volumizing hyaluronic acid filler in treating midface volume deficit. Dermatol Surg. 2015; 41(8):942-9. DOI: 10.1097/DSS.0000000000000416. View

18.

Afra T, Vinay K, Razmi T M, Narang T, Dogra S . Hyaluronic acid fillers for correcting midface volume deficit in Barraquer-Simons syndrome. J Cosmet Dermatol. 2019; 18(5):1264-1266. DOI: 10.1111/jocd.12847. View

19.

Scott D, Amos N, Sissons J, LACHMANN P, PETERS D . The immunogloblin nature of nephritic factor (NeF). Clin Exp Immunol. 1978; 32(1):12-24. PMC: 1541306. View

20.

Coessens B, Van Geertruyden J . Simultaneous bilateral facial reconstruction of a Barraquer-Simons lipodystrophy with free TRAM flaps. Plast Reconstr Surg. 1995; 95(5):911-5. View