Promising Advances in Clinical Trials of Dental Tissue-derived Cell-based Regenerative Medicine

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2020 May 14

PMID 32398041

Citations 30

Authors

Yoichi Yamada

Sayaka Nakamura-Yamada

Ryutaro Konoki

Shunsuke Baba

Affiliations

Soon will be listed here.

Abstract

Background: Advances in regenerative medicine with stem cells have led to clinical trials. Dental/oral tissues are emerging as promising cellular sources of human mesenchymal stem cells. Recently, dental tissue-derived cells have been used clinically due to their great potential, easy accessibility, and ability to be obtained via methods with low invasiveness. The aim of this study is to systematically assess the clinical effectiveness of dental cell-mediated therapies compared to current evidence-based methods in human patients.

Methods: The electronic databases MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched up to December 2019 for clinical trials. Clinical trials with any intervention using stem cells/cells derived from dental tissue were included.

Results: A total of 815 studies were identified by the electronic search, and 38 articles qualified for full-text evaluation. Finally, 20 studies (10 clinical trials using dental pulp-derived cells, 3 clinical trials using periodontal ligament-derived cells, and 7 studies using gingiva-derived cells) were included in this review. No clinical trials using dental follicle- or apical papilla-derived cells were selected in this review. Dental pulp-derived cells were used in clinical trials for bone regeneration, periodontitis, and dental pulp regeneration. All clinical trials using periodontal ligament-derived cells and gingiva-derived cells were conducted for periodontal disease treatment and gingival augmentation, respectively. Among the 20 selected studies, 16 showed clinical benefits of cell transplantation therapies. In addition, no study reported adverse events that may have been associated with cell transplantation.

Conclusions: These findings indicate that dental tissue-derived cells would be useful for cell-based regenerative medicine for various diseases.

Citing Articles

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The next generation of regenerative dentistry: From tooth development biology to periodontal tissue, dental pulp, and whole tooth reconstruction in the clinical setting.

Morita K, Wang J, Okamoto K, Iwata T Regen Ther. 2025; 28:333-344.

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Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration.

Zhao D, Yang R, Wei H, Yang K, Yang Y, Wang N Front Immunol. 2025; 15():1449411.

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