COVID-19 Pandemic: an Overview of Epidemiology, Pathogenesis, Diagnostics and Potential Vaccines and Therapeutics

Overview

Journal Ther Deliv

Date 2020 May 14

PMID 32397911

Citations 72

Authors

Haneen Amawi

Ghinaa I Abu Deiab

Alaa A A Aljabali

Kamal Dua

Murtaza M Tambuwala

Affiliations

Soon will be listed here.

Abstract

At the time of writing this review, severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2) has infected more than 2,355,853 patients and resulted in more than 164,656 deaths worldwide (as of 20 April 2020). This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. Several antivirals, antimalarials and immunomodulators that have shown activity against SARS-CoV and Middle East coronavirus respiratory syndromes are being evaluated. In particular, hydroxychloroquine, remdesivir, favipiravir, arbidol, tocilizumab and bevacizumab have shown promising results. The main aim of this review is to provide an overview of this pandemic and where we currently stand.

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