CD24 Blunts the Sensitivity of Retinoblastoma to Vincristine by Modulating Autophagy

Overview

Journal Mol Oncol

Specialties Molecular Biology
Oncology

Date 2020 May 13

PMID 32394616

Citations 20

Authors

Jie Sun

Dongju Feng

Huiyu Xi

Jiajing Luo

Zewei Zhou

Qinghuai Liu

Yun Chen

Qing Shao

Affiliations

Soon will be listed here.

Abstract

Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI-anchored protein, was overexpressed in human RB tissues and RB cell lines, and was associated with the sensitivity of RB cells in response to VCR therapy. We demonstrated that CD24 plays a critical role in impairing RB sensitivity to VCR via regulating autophagy. Mechanistically, CD24 recruits PTEN to the lipid raft domain and regulates the PTEN/AKT/mTORC1 pathway to activate autophagy. Lipid raft localization was essential for CD24 recruitment function. Collectively, our findings revealed a novel role of CD24 in regulating RB sensitivity to VCR and showed that CD24 is a potential target for improving chemotherapeutic sensitivity and RB patient outcomes.

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