Utility of Photodynamic Therapy in Dentistry: Current Concepts

Overview

Journal Dent J (Basel)

Specialty Dentistry

Date 2020 May 13

PMID 32392793

Citations 29

Authors

Anette Stajer

Szilvia Kajari

Mario Gajdacs

Aima Musah-Eroje

Zoltan Barath

Affiliations

Soon will be listed here.

Abstract

The significant growth in scientific and technological advancements within the field of dentistry has resulted in a wide range of novel treatment modalities for dentists to use. Photodynamic therapy (PDT) is an emerging, non-invasive treatment method, involving photosensitizers, light of a specific wavelength and the generation of singlet oxygen and reactive oxygen species (ROS) to eliminate unwanted eukaryotic cells (e.g., malignancies in the oral cavity) or pathogenic microorganisms. The aim of this review article is to summarize the history, general concepts, advantages and disadvantages of PDT and to provide examples for current indications of PDT in various subspecialties of dentistry (oral and maxillofacial surgery, oral medicine, endodontics, preventive dentistry, periodontology and implantology), in addition to presenting some images from our own experiences about the clinical success with PDT.

Citing Articles

Advanced Lasers and Their Applications in Dentistry.

Zhang O, Yin I, Yu O, Luk K, Niu J, Chu C Dent J (Basel). 2025; 13(1).

PMID: 39851613 PMC: 11763962. DOI: 10.3390/dj13010037.

The impact of antimicrobial photodynamic therapy on pain and oral health-related quality of life: A literature review.

Bahrami R, Pourhajibagher M, Nikparto N, Bahador A J Dent Sci. 2024; 19(4):1924-1933.

PMID: 39347022 PMC: 11437269. DOI: 10.1016/j.jds.2024.06.022.

Efficacy of Aminolevulinic Acid Mediated Photodynamic Therapy in the Treatment of Oral Premalignant Lesions: A Systematic Review.

Bordoloi B, Goswami A, Roy D, Goswami P, Das I Asian Pac J Cancer Prev. 2024; 25(9):2971-2978.

PMID: 39342573 PMC: 11700322. DOI: 10.31557/APJCP.2024.25.9.2971.

Evaluating the potency of laser-activated antimicrobial photodynamic therapy utilizing methylene blue as a treatment approach for chronic periodontitis.

Perumal M, Renuka R, Natarajan P Front Oral Health. 2024; 5:1407201.

PMID: 38872983 PMC: 11169725. DOI: 10.3389/froh.2024.1407201.

The power of light - From dental materials processing to diagnostics and therapeutics.

Hadis M, Shortall A, Palin W Biomater Investig Dent. 2024; 11:40308.

PMID: 38645925 PMC: 11022655. DOI: 10.2340/biid.v11.40308.

References

Okamoto C, Motta L, Prates R, Costa da Mota A, Goncalves M, Tempestini Horliana A . Antimicrobial Photodynamic Therapy as a Co-adjuvant in Endodontic Treatment of Deciduous Teeth: Case Series. Photochem Photobiol. 2018; 94(4):760-764. DOI: 10.1111/php.12902. View

Allison R, Downie G, Cuenca R, Hu X, Childs C, Sibata C . Photosensitizers in clinical PDT. Photodiagnosis Photodyn Ther. 2014; 1(1):27-42. DOI: 10.1016/S1572-1000(04)00007-9. View

Rkein A, Ozog D . Photodynamic therapy. Dermatol Clin. 2014; 32(3):415-25, x. DOI: 10.1016/j.det.2014.03.009. View

Kumar V, Sinha J, Verma N, Nayan K, Saimbi C, Tripathi A . Scope of photodynamic therapy in periodontics. Indian J Dent Res. 2015; 26(4):439-42. DOI: 10.4103/0970-9290.167636. View

Garcez A, Nunez S, Hamblin M, Ribeiro M . Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. J Endod. 2008; 34(2):138-42. PMC: 2808698. DOI: 10.1016/j.joen.2007.10.020. View

Komerik N, MacRobert A . Photodynamic therapy as an alternative antimicrobial modality for oral infections. J Environ Pathol Toxicol Oncol. 2006; 25(1-2):487-504. DOI: 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.310. View

Mallidi S, Anbil S, Lee S, Manstein D, Elrington S, Kositratna G . Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema. J Biomed Opt. 2014; 19(2):028001. PMC: 3915169. DOI: 10.1117/1.JBO.19.2.028001. View

Kou J, Dou D, Yang L . Porphyrin photosensitizers in photodynamic therapy and its applications. Oncotarget. 2017; 8(46):81591-81603. PMC: 5655312. DOI: 10.18632/oncotarget.20189. View

Stajer A, Urban E, Pelsoczi I, Mihalik E, Rakonczay Z, Nagy K . Effect of caries preventive products on the growth of bacterial biofilm on titanium surface. Acta Microbiol Immunol Hung. 2012; 59(1):51-61. DOI: 10.1556/AMicr.59.2012.1.6. View

10.

Sitnik T, Hampton J, Henderson B . Reduction of tumour oxygenation during and after photodynamic therapy in vivo: effects of fluence rate. Br J Cancer. 1998; 77(9):1386-94. PMC: 2150183. DOI: 10.1038/bjc.1998.231. View

11.

Petersen J, Glassl E, Nasseri P, Crismani A, Luger A, Schoenherr E . The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. Clin Oral Investig. 2013; 18(7):1813-23. PMC: 4145204. DOI: 10.1007/s00784-013-1156-3. View

12.

LIPSON R, BALDES E . The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol. 1960; 82:508-16. DOI: 10.1001/archderm.1960.01580040026005. View

13.

Misra A, Rai S, Misra D . Functional role of apoptosis in oral diseases: An update. J Oral Maxillofac Pathol. 2016; 20(3):491-496. PMC: 5051299. DOI: 10.4103/0973-029X.190953. View

14.

Fimple J, Fontana C, Foschi F, Ruggiero K, Song X, Pagonis T . Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod. 2008; 34(6):728-34. PMC: 2596687. DOI: 10.1016/j.joen.2008.03.011. View

15.

Tampa M, Sarbu M, Matei C, Mitran C, Mitran M, Caruntu C . Photodynamic therapy: A hot topic in dermato-oncology. Oncol Lett. 2019; 17(5):4085-4093. PMC: 6444307. DOI: 10.3892/ol.2019.9939. View

16.

Abd El-Kaream S, Abd Elsamie G, Abd-Alkareem A . Sono-photodynamic modality for cancer treatment using bio-degradable bio-conjugated sonnelux nanocomposite in tumor-bearing mice: Activated cancer therapy using light and ultrasound. Biochem Biophys Res Commun. 2018; 503(2):1075-1086. DOI: 10.1016/j.bbrc.2018.06.119. View

17.

Sharma P, Wadhwan V, Aggarwal P, Sharma A . Oral verrucous hyperplasia versus oral verrucous carcinoma: A clinicopathologic dilemma revisited using p53 as immunohistochemical marker. J Oral Maxillofac Pathol. 2016; 20(3):362-368. PMC: 5051281. DOI: 10.4103/0973-029X.190902. View

18.

Detty M, Gibson S, Wagner S . Current clinical and preclinical photosensitizers for use in photodynamic therapy. J Med Chem. 2004; 47(16):3897-915. DOI: 10.1021/jm040074b. View

19.

Raghavendra M, Koregol A, Bhola S . Photodynamic therapy: a targeted therapy in periodontics. Aust Dent J. 2009; 54 Suppl 1:S102-9. DOI: 10.1111/j.1834-7819.2009.01148.x. View

20.

Rautemaa R, Lauhio A, Cullinan M, Seymour G . Oral infections and systemic disease--an emerging problem in medicine. Clin Microbiol Infect. 2007; 13(11):1041-7. DOI: 10.1111/j.1469-0691.2007.01802.x. View