Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 May 12

PMID 32391002

Citations 7

Authors

Dong-Jin Kim

Ju-Young Moon

Su-Mi Kim

Jung-Woo Seo

Yu Ho Lee

Su Woong Jung

Kipyo Kim

Yang Gyun Kim

Sung-Jig Lim

Sangju Lee

Youngsook Son

Sang-Ho Lee

Affiliations

Soon will be listed here.

Abstract

Substance P (SP), an injury-inducible messenger that mobilizes bone marrow stem cells and modulates the immune response, has been suggested as a novel target for therapeutic agents. We evaluated the role of SP as an immune cell modulator during the progression of renal ischemic/reperfusion injury (IRI). Unilateral IRI induced the transient expression of endogenous SP and the infiltration of CCR7 M1 macrophages in injured kidneys. However, SP altered the intrarenal macrophage polarization from CCR7 M1 macrophages to CD206 M2 macrophages in injured kidneys. SP also modulated bone marrow-derived neutrophils and mesenchymal stromal cells after IRI. SP treatment for 4 weeks starting one week after unilateral IRI significantly preserved kidney size and length and normal tubular structures and alleviated necrotic tubules, inflammation, apoptosis, and tubulointerstitial fibrosis. The beneficial effects of SP were accompanied by attenuation of intrarenal recruitment of CD4, CD8, and CD20 cells and abnormal angiogenesis. The immunomodulatory effect of SP suggested that SP could be a promising therapeutic target for preventing the progression of acute kidney injury to chronic kidney disease.

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