Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2020 May 10

PMID 32384813

Citations 53

Authors

Shokoh Parham

Anousheh Zargar Kharazi

Hamid Reza Bakhsheshi-Rad

Hamid Ghayour

Ahmad Fauzi Ismail

Hadi Nur

Filippo Berto

Affiliations

Soon will be listed here.

Abstract

Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.

Citing Articles

Electrospinning: A New Frontier in Peptide Therapeutics.

L J, Kamaraj S, Kandasamy R, Alagarsamy S AAPS PharmSciTech. 2025; 26(3):69.

PMID: 40011310 DOI: 10.1208/s12249-025-03054-2.

A multifunctional photothermal electrospun PLGA/MoS@Pd nanofiber membrane for diabetic wound healing.

Chen Z, Mo Q, Mo D, Pei X, Liang A, Cai J Regen Biomater. 2025; 12:rbae143.

PMID: 39850758 PMC: 11754638. DOI: 10.1093/rb/rbae143.

Enhancement of antibacterial activity in electrospun fibrous membranes based on quaternized chitosan with caffeic acid and berberine chloride for wound dressing applications.

Chiu P, Wu Z, Hsu C, Chang Y, Huang C, Hu C RSC Adv. 2024; 14(47):34756-34768.

PMID: 39483382 PMC: 11526035. DOI: 10.1039/d4ra05114a.

Development of Cerium Oxide-Laden GelMA/PCL Scaffolds for Periodontal Tissue Engineering.

Aminmansour S, Cardoso L, Anselmi C, de Carvalho A, Rahimnejad M, Bottino M Materials (Basel). 2024; 17(16).

PMID: 39203082 PMC: 11355598. DOI: 10.3390/ma17163904.

Bioengineered 3D ovarian model for long-term multiple development of preantral follicle: bridging the gap for poly(ε-caprolactone) (PCL)-based scaffold reproductive applications.

Di Berardino C, Peserico A, Camerano Spelta Rapini C, Liverani L, Capacchietti G, Russo V Reprod Biol Endocrinol. 2024; 22(1):95.

PMID: 39095895 PMC: 11295475. DOI: 10.1186/s12958-024-01266-y.

References

Petrova V, Chernyakov D, Poshina D, Gofman I, Romanov D, Mishanin A . Electrospun Bilayer Chitosan/Hyaluronan Material and Its Compatibility with Mesenchymal Stem Cells. Materials (Basel). 2019; 12(12). PMC: 6631200. DOI: 10.3390/ma12122016. View

Brannon-Peppas L, Ghosn B, Roy K, Cornetta K . Encapsulation of nucleic acids and opportunities for cancer treatment. Pharm Res. 2007; 24(4):618-27. DOI: 10.1007/s11095-006-9208-x. View

Koosha M, Raoufi M, Moravvej H . One-pot reactive electrospinning of chitosan/PVA hydrogel nanofibers reinforced by halloysite nanotubes with enhanced fibroblast cell attachment for skin tissue regeneration. Colloids Surf B Biointerfaces. 2019; 179:270-279. DOI: 10.1016/j.colsurfb.2019.03.054. View

Singh A, Rath G, Singh R, Goyal A . Nanofibers: An Effective Tool for Controlled and Sustained Drug Delivery. Curr Drug Deliv. 2017; 15(2):155-166. DOI: 10.2174/1567201814666171002115230. View

Wang X, Ding B, Sun G, Wang M, Yu J . Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets. Prog Mater Sci. 2020; 58(8):1173-1243. PMC: 7112371. DOI: 10.1016/j.pmatsci.2013.05.001. View

Tra Thanh N, Ho Hieu M, Tran Minh Phuong N, Do Bui Thuan T, Nguyen Thi Thu H, Thai V . Optimization and characterization of electrospun polycaprolactone coated with gelatin-silver nanoparticles for wound healing application. Mater Sci Eng C Mater Biol Appl. 2018; 91:318-329. DOI: 10.1016/j.msec.2018.05.039. View

Datta S, Rameshbabu A, Bankoti K, Maity P, Das D, Pal S . Oleoyl-Chitosan-Based Nanofiber Mats Impregnated with Amniotic Membrane Derived Stem Cells for Accelerated Full-Thickness Excisional Wound Healing. ACS Biomater Sci Eng. 2021; 3(8):1738-1749. DOI: 10.1021/acsbiomaterials.7b00189. View

Paneva D, Manolova N, Argirova M, Rashkov I . Antibacterial electrospun poly(ɛ-caprolactone)/ascorbyl palmitate nanofibrous materials. Int J Pharm. 2011; 416(1):346-55. DOI: 10.1016/j.ijpharm.2011.06.032. View

Luu Y, Kim K, Hsiao B, Chu B, Hadjiargyrou M . Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release. 2003; 89(2):341-53. DOI: 10.1016/s0168-3659(03)00097-x. View

10.

Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B . Electrospun cellular microenvironments: Understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2010; 63(4-5):209-20. DOI: 10.1016/j.addr.2010.12.002. View

11.

Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu X . Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Control Release. 2005; 105(1-2):43-51. DOI: 10.1016/j.jconrel.2005.02.024. View

12.

Farokhi M, Mottaghitalab F, Fatahi Y, Khademhosseini A, Kaplan D . Overview of Silk Fibroin Use in Wound Dressings. Trends Biotechnol. 2018; 36(9):907-922. DOI: 10.1016/j.tibtech.2018.04.004. View

13.

Zhang H, Lou S, Williams G, Branford-White C, Nie H, Quan J . A systematic study of captopril-loaded polyester fiber mats prepared by electrospinning. Int J Pharm. 2012; 439(1-2):100-8. DOI: 10.1016/j.ijpharm.2012.09.055. View

14.

Kandhasamy S, Perumal S, Madhan B, Umamaheswari N, Banday J, Perumal P . Synthesis and Fabrication of Collagen-Coated Ostholamide Electrospun Nanofiber Scaffold for Wound Healing. ACS Appl Mater Interfaces. 2017; 9(10):8556-8568. DOI: 10.1021/acsami.6b16488. View

15.

Zhou Y, Yang D, Chen X, Xu Q, Lu F, Nie J . Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules. 2007; 9(1):349-54. DOI: 10.1021/bm7009015. View

16.

Chouhan D, Chakraborty B, Nandi S, Mandal B . Role of non-mulberry silk fibroin in deposition and regulation of extracellular matrix towards accelerated wound healing. Acta Biomater. 2016; 48:157-174. DOI: 10.1016/j.actbio.2016.10.019. View

17.

Monteiro N, Martins M, Martins A, Fonseca N, Moreira J, Reis R . Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin. Acta Biomater. 2015; 18:196-205. DOI: 10.1016/j.actbio.2015.02.018. View

18.

Abrigo M, McArthur S, Kingshott P . Electrospun nanofibers as dressings for chronic wound care: advances, challenges, and future prospects. Macromol Biosci. 2014; 14(6):772-92. DOI: 10.1002/mabi.201300561. View

19.

Hidalgo Pitaluga L, Souza M, Zanotto E, Santocildes Romero M, Hatton P . Electrospun F18 Bioactive Glass/PCL-Poly (ε-caprolactone)-Membrane for Guided Tissue Regeneration. Materials (Basel). 2018; 11(3). PMC: 5872979. DOI: 10.3390/ma11030400. View

20.

Kurtz I, Schiffman J . Current and Emerging Approaches to Engineer Antibacterial and Antifouling Electrospun Nanofibers. Materials (Basel). 2018; 11(7). PMC: 6073658. DOI: 10.3390/ma11071059. View