Genomic Identification, Evolution, and Expression Analysis of Collagen Genes Family in Water Buffalo During Lactation

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 May 10

PMID 32384775

Citations 6

Authors

Xingrong Lu

Anqin Duan

Shasha Liang

Xiaoya Ma

Tingxian Deng

Affiliations

Soon will be listed here.

Abstract

Collagens, as extracellular matrix proteins, support cells for structural integrity and contribute to support mammary basic structure and development. This study aims to perform the genomic identification, evolution, and expression analyses of the collagen gene family in water buffalo () during lactation. A total of 128 buffalo collagen protein sequences were deduced from the 45 collagen genes identified in silico from buffalo genome, which classified into six groups based on their phylogenetic relationships, conserved motifs, and gene structure analyses. The identified collagen sequences were unequally distributed on 16 chromosomes. The tandem duplicated genes were found within three chromosomes, while only one segmental event occurred between Chr3 and Chr8. Collinearity analysis revealed that a total of 36 collagen gene pairs were orthologous between buffalo and cattle genomes despite having different chromosome numbers. Comparative transcription analyses revealed that a total of 23 orthologous collagen genes were detected in the milk samples at different lactation periods between the two species. Notably, the duplicated gene pair of during lactation had a higher mRNA expression level than that of cattle, while a higher expression level of pair was found in cattle compared with that of buffalo. The present study provides useful information for investigating the potential functions of the collagen family in buffalo during lactation and helps in the functional characterization of collagen genes in additional research.

Citing Articles

In Silico Analysis: Molecular Characterization and Evolutionary Study of Gene Family in Buffalo.

Fu Y, Khan M, Wang Y, Parveen S, Sultana M, Liu Q Genes (Basel). 2024; 15(9).

PMID: 39336754 PMC: 11431104. DOI: 10.3390/genes15091163.

Genome-Wide Identification, Evolutionary and Mutational Analysis of the Buffalo Sox Gene Family.

Abdullah M, Rehman M, Rehman M, Alkahtane A, Al-Hazani T, Hassan F Animals (Basel). 2023; 13(14).

PMID: 37508024 PMC: 10376873. DOI: 10.3390/ani13142246.

Genomic Identification, Evolution, and Expression Analysis of Bromodomain Genes Family in Buffalo.

Zhang J, Huang L, Zhang P, Huang X, Yang W, Liu R Genes (Basel). 2022; 13(1).

PMID: 35052443 PMC: 8774554. DOI: 10.3390/genes13010103.

Integrative Systems Biology Analysis Elucidates Mastitis Disease Underlying Functional Modules in Dairy Cattle.

Ghahramani N, Shodja J, Rafat S, Panahi B, Hasanpur K Front Genet. 2021; 12:712306.

PMID: 34691146 PMC: 8531812. DOI: 10.3389/fgene.2021.712306.

Genome-Wide Association Studies for Milk Somatic Cell Score in Romanian Dairy Cattle.

Ilie D, Mizeranschi A, Mihali C, Neamt R, Goilean G, Georgescu O Genes (Basel). 2021; 12(10).

PMID: 34680890 PMC: 8535694. DOI: 10.3390/genes12101495.

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