Epigenome-wide Association Study Reveals CpG Sites Related to COG of Neuroblastoma

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2020 May 8

PMID 32378698

Citations 1

Authors

Hao Zhao

Xiaojun Zhou

Hu Sun

Dongyun Zhao

Hongfei Liu

Bin Huang

Xingang Li

Yinghao Gu

Affiliations

Soon will be listed here.

Abstract

Background: Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children. Its variable location and complex pathogenesis make NB hard for early diagnosis and risk classification.

Methodology: We analyzed the methylation data of 236 samples from patients with NB in Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Kaplan-Meier survival analysis was used for comparing overall survival of NB patients in different groups. Epigenome-wide association study (EWAS) was conducted to screen CpGs significantly associated with NB patients' Children's Oncology Group (COG). Logistic regression method was used for constructing a model to predict NB patients' COG.

Results: NB patients in low COG showed significantly superior prognosis than those in high COG. A total of seven CpG sites were found closely related to COG. Logistic regression model based on those CpGs showed superior performance in separating NB patients in different COGs.

Conclusions: The present study highlights the important role of DNA methylation in NB development, which might provide evidence for treatment decisions for children NB.

Citing Articles

Identification of a ferroptosis-related gene signature for the prognosis of pediatric neuroblastoma.

Lin X, Shao K, Lin Z, Liang Q, Li X, Chen H Transl Cancer Res. 2024; 13(7):3678-3694.

PMID: 39145053 PMC: 11319987. DOI: 10.21037/tcr-24-269.

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