Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Overview

Journal Adv Pharm Bull

Date 2020 May 7

PMID 32373485

Citations 99

Authors

Iti Chauhan

Mohd Yasir

Madhu Verma

Alok Pratap Singh

Affiliations

Soon will be listed here.

Abstract

Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.

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