Cajanin Stilbene Acid Inhibited Vancomycin-Resistant by Inhibiting Phosphotransferase System

Overview

Journal Front Pharmacol

Date 2020 May 7

PMID 32372958

Citations 9

Authors

Shengnan Tan

Xin Hua

Zheyong Xue

Jianzhang Ma

Affiliations

Soon will be listed here.

Abstract

Antimicrobial resistance has become a serious threat to human and animal health, and vancomycin-resistant has become an important nosocomial infection pathogen, causing thousands of deaths each year. In this study, after screening a variety of natural products, we found that cajanin stilbene acid (CSA) had significant inhibitory effect on sensitive and vancomycin-resistant (VRE) . And we also confirmed that CSA had significant anti-VRE infection ability . Subsequently, we studied the antibacterial mechanism of CSA through proteomics experiments, and the results showed that CSA killed by inhibiting the phosphotransferase system of , thus hinders the normal growth and metabolic functions of bacteria. The results of this study provided evidence for the in-depth study on the mechanism of the antibacterial action of CSA and also provided a candidate for the development of anti-VRE drugs.

Citing Articles

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