Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 May 6

PMID 32365518

Citations 25

Authors

Ramandeep Kaur

Pooja Sharma

Girish K Gupta

Fidele Ntie-Kang

Dinesh Kumar

Affiliations

Soon will be listed here.

Abstract

Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus named Human Immunodeficiency Virus (HIV), has impacted about 70 million people worldwide. Even though several advances have been made in the field of antiretroviral combination therapy, HIV is still responsible for a considerable number of deaths in Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. Presently, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate drugs derived from plants as well as their derivatives. Several plants, such as , , , , , and others have displayed significant anti-HIV activity. Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV activity along with their mechanisms of action and IC values, structure-activity-relationships and important key findings.

Citing Articles

Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint.

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Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3'-Processing Suppression.

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