[Biology of Lectins and Their Application in Clinical Biochemistry (author's Transl)]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1977 Apr 15

PMID 323566

Citations 5

Authors

E Kottgen

Affiliations

Soon will be listed here.

Abstract

Lectins are proteins or glycoproteins, originally isolated from plant seeds. Characteristics are their ability to bind glycoproteins or glycolipids depending on the carbohydrate residues. The present review describes the structure of the lectins, their binding specificity and their functions with respect to precipitation of glycoproteins, agglutination of cells, transformation of lymphocytes and toxic action. Recently, lectin-analogs have been described in rabbit liver, which are responsible for hepatic uptake of circulating glycoproteins. The regulation of this process is intimately linked to the terminal N-Acetylneuraminic acid (NA-NA). Moreover, its significance is shown during fetal development, oncogenic transformation, immunologic recognition as well as homostasis. Due to the different terminal carbohydrate residues, glycoproteins of adult, fetal or transformed cells can be separated using affinity chromatography. Besides the purification of glycoproteins, lectins are also used for the separation of intact cells. Therefore the use of lectins is recommended for preparative and analytical methods, for the measurements of glycoprotein-turnover and for clinical diagnostics.

Citing Articles

[Lectins, toxins and immunotoxins].

Uhlenbruck G Naturwissenschaften. 1981; 68(12):606-12.

PMID: 7335119 DOI: 10.1007/BF00398611.

[Gluten-sensitive enteropathy--in the light of new clinical and pathogenetic aspects].

Kluge F, Koch H, Kottgen E, Gerok W Klin Wochenschr. 1983; 61(14):669-79.

PMID: 6350694 DOI: 10.1007/BF01487612.

Role of membrane glycoproteins in mediating trophic responses.

Tauber R, REUTTER W, Gerok W Gut. 1987; 28 Suppl:71-7.

PMID: 3319814 PMC: 1434538. DOI: 10.1136/gut.28.suppl.71.

Demonstration of giant and anular nexus in the psoriatic epidermis.

Mahrle G Arch Dermatol Res. 1978; 261(2):181-8.

PMID: 655736 DOI: 10.1007/BF00447163.

[Glycoproteins: their biological and clinical significance. II (author's transl)].

Kottgen E, Bauer C, REUTTER W, Gerok W Klin Wochenschr. 1979; 57(5):199-214.

PMID: 431030 DOI: 10.1007/BF01477489.

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